关键词:高强度超声;彩色多普勒能量图;肿瘤血管
摘 要 目的:观察高强度超声(HIU)对肿瘤营养血管的破坏作用。方法:采用二维灰阶、彩色多普勒能量图和病理结合的方法,观察HIU对兔VX2 肝脏肿瘤营养血管破坏的情况。结果:HIU治疗后,肿瘤组织回声增强,彩色多普勒能量图显示肿瘤组织内部血管影明显减少或消失,病理学检查方法显示肿瘤营养血管和肿瘤组织凝固性坏死。结论:HIU可能较完全破坏肿瘤营养血管,从而有可能抑制肿瘤的再生和转移,促使肿瘤良性化。
The Damage Effect of HighIntensity Ultrasound on the Rabbit Liver Carcinoma Vascularities Observed with ColorDoppler Energy and Pathology
Guan Liming,Ran Haitao,Wu Feng,et al
(Institute of Ulstrasound Engneering in Medicine,Chongqing Medical University,Chongqing China 400016)
ABSTRACT Objective:To evaluate thedamage effect of high intensity ulstrasound(HIU)for carcinomatic vascularities.The effectis important for HIU to inhibitit tumor growth,metastases and transfer it into benignstate.Methods:The animal models of the VX2 tumor in the rabbit liver were setup,and histological examination combined with grey scale ultrasonography and the colorDoppler energy was observed.Results:After HIU treatment,the ultrasonography echo intensityof tumor tissue was increased,while the imaging of carcnoma vascularities with the tumorwere decreased or dismissed.Histological examination indicated that HIU made carcinomavascularities within the whole tumor tissue coagulative necrosis.Conclusions:HIU maydamage carcinoma vascularities thoroughly,in such away it may inhibit tumor growth andmetastases,that makes tumor return benign form.
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