胞苷脱氨酶基因对小鼠大剂量化疗的保护作用
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路 平, 王永来, 金 锋, 陈 波, 姚
胞苷脱氨基酶基因;基因疗法;阿糖胞苷,路平,金锋,陈波,姚凡,王舒宝,陈峻青,徐惠绵,王永来,赵实诚,通讯作者,:,Protectionofcytidin
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路平, 金锋, 陈波, 姚凡, 王舒宝, 陈峻青, 徐惠绵 , 中国医科大学附属第一医院肿瘤科 辽宁省沈阳市 110001
王永来 , 中国医科大学附属第二医院妇产科 辽宁省沈阳市 110004
赵实诚 , 美国纽约史隆-凯特林肿瘤研究所 纽约 10021
路平, 男, 1964-02-13生, 安徽省萧县人, 汉族, 1998年中国医科大学博士, 副教授, 主要从事消化道肿瘤的诊治研究.
国家自然科学基金资助项目, No. 30471678
通讯作者 : 路平, 110001, 辽宁省沈阳市和平区南京北街155号, 中国医科大学附属第一医院肿瘤科. lupingllll@yahoo.com
电话: 024-23256666-6227 传真: 024-23265477
收稿日期: 2005-06-23 接受日期: 2005-06-30
Protection of cytidine deaminase gene gainst toxicity of high-dose chemotherapy in mice
Ping Lu, Yong-Lai Wang, Fen Jin, Buo Chen, Fan Yao, Shu-Bao Wang, Jun-Qing Chen, Hui-Mian Xu, Shi-Cheng Zhao
Ping Lu, Fen Jin, Buo Chen, Fan Yao, Shu-Bao Wang, Jun-Qing Chen, Hui-Mian Xu, Department of Oncology, the First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, China
Yong-Lai Wang, Department of Gynecology, the Second Affiliated Hospital, China Medical University, Shenyang 110004, Liaoning Province, China
Shi-Cheng Zhao, Memorial Sloan-Kettering Cancer Center, New York 10021, U.S.A
Supported by National Natural Science Foundation of China, No. 30471678
Correspondence to: Dr.Ping Lu, Department of Oncology, the First Affiliated Hospital, China Medical University, 155 Nanjing Beijie, Shenyang 110001, Liaoning Province, China. Lupingllll@yahoo.com
Received: 2005-06-23 Accepted: 2005-06-30
Abstract
AIM: To observe the tolerance to high-dose cytarabine (Ara-C) in mice after the cytidine deaminase (CD) gene is transfected into mouse bone marrow cells, and to explore the feasibility of chemotherapy combined with the tolerance of myelosuppression ......
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