小鼠实验性胃溃疡病理变化评定标准的量化
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王晓洁, 杨立红, 梁建光
胃溃疡模型;图像积分法;称质量法;溃疡面积比,王晓洁,杨立红,梁建光,通讯作者,:,Pathologicalquantificationofexperime
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王晓洁, 杨立红, 梁建光 , 烟台师范学院生物科学与技术系
山东省烟台市 264025
王晓洁, 女, 1962-10-23生, 山东省青岛市人, 汉族, 1985年青岛医学院学士, 2005年中国海洋大学博士, 副教授, 主要从事动物病害及药理学的研究.
烟台师范学院科学研究项目, No. 280111
通讯作者 : 王晓洁, 264025, 山东省烟台市红旗路180号, 烟台师范学院生物科学与技术系. xiaojiewang@etang.com
电话: 0535-6681053 传真: 0535-6672269
收稿日期: 2005-01-31 接受日期: 2005-03-16
Pathological quantification of experimental gastric ulcer in mice
Xiao-Jie Wang, Li-Hong Yang, Jian-Guang Liang
Xiao-Jie Wang, Li-Hong Yang, Jian-Guang Liang, Department of Bioscience and Technology, Yantai Normal University, Yantai 264025, Shandong Province, China
Supported by the Foundation of Yantai Normal University Science, No.280111
Correspondence to: Dr. Xiao-Jie Wang, Department of Bioscience and Technology, Yantai Normal University, 180 Hongqi Road, Yantai 264025, Shandong Province China. xiaojiewang@etang.com
Received: 2005-01-31 Accepted: 2005-03-16
Abstract
AIM: To develop a method of quantifying the pathological changes gastric ulcer in the experimental mice.
METHODS: The experimental mice were fed with alcohol to establish the model of gastric ulcer. The area of the ulcer was quantified by weight and picture integration. Then the ratio of ulcer area to total stomach area (ulcer area ratio, UAR) was calculated to assess the degrees of the ulcers on the stomach wall. Furthermore, the methods of weighing, picture integration, marking, and grading were compared.
RESULTS: The mark indexes and the UAR by weight and picture integration were significantly different between different grading groups (Grade 4 vs Grade 2 vs Grade 1: 84.0±27.8 vs 19.6±8.1 vs 4.0±1.0, P<0.05; 40.74±0.26% vs 4.22±0.01% vs 1.03±0.01%, P<0.05; 31.57 ±0.16% vs 4.36±0.02% vs 2.43±0.02%, P<0.05) respectively, but the petechiae have no significant difference (P>0 ......
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