虫草菌丝对大鼠实验性肝纤维化肝细胞增生的影响
项目负责人,EffectofCordycepssinensisonhepatocyticproliferationofexperimentalhepaticfibrosisinrats,Correspondenceto:,Abstract,AIM:,METHODS:,RESULTS:,CONCLUSION:,摘要,目的:,方法:,结果:,结论:,0引言,1材料和方法,1
刘玉侃,沈薇,重庆医科大学第二临床学院消化内科 重庆市 400010沈薇,重庆医科大学第二临床学院消化内科主任 重庆市 400010
刘玉侃,1994年毕业于北京中医药大学,2001年重庆医科大学硕士研究生毕业.
项目负责人 沈薇,400010,重庆医科大学第二临床学院消化内科
电话: 023-63784155
收稿日期 2002-01-26 接受日期 2002-02-19
Effect of Cordyceps sinensis on hepatocytic proliferation of experimental hepatic fibrosis in rats
Yu-Kan Liu, Wei Shen
Yu-Kan Liu, Wei Shen. Chongqing University of Medical Sciences, Chongqing 400010, China
Correspondence to: Wei Shen, Chongqing University of Medical Sciences, Chongqing 400010, China
Received 2002-01-26 Accepted 2002-02-19
Abstract
AIM:To dynamically investigate the effect of Cordyceps sinensis (CS) on hepatocytic proliferation in CCL4-plus ethanol-induced hepatic fibrosis in rats.
METHODS:Rats were randomly allocated into a normal control group, a model control group and a CS group. The latter two groups were administered with CCL4 and ethanol solution to induce hepatic fibrosis. The CS group was also treated with CS 10 days after the beginning of CCL4 and ethanol administration. Rats in normal control group were sacrificed at the beginning of experiment. Other two groups were sacrificed randomly at the end of the third, the sixth and the ninth week. Blood and tissue specimens were taken. Biochemical and immunohistochemical assays were used respectively to determine the hepatocyte degenerative index (HDI), the level of albumin in serum and PCNA, HGF expression in liver tissue. ......
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