【摘要】 目的 为了检验葡萄多酚的生物安全性。 方法 对葡萄多酚样品进行小鼠急性毒性实验和小鼠遗传毒性实验。 结果 小鼠急性和遗传毒性测试均为阴性。对大鼠喂养30天的实验表明，在实验期内各实验组动物生长发育良好，动物体重、食物利用率、血常规、血生化、脏器系数等各项指标均在正常值范围内，与对照组之间差异无显著性(P>0.05)。病理组织学检查无异常。 结论 表明该物质对大鼠各项观察指标未产生明显毒性作用。

    【关键词】 葡萄多酚;毒理学

    Study on toxicology of grape procyanidins

    ZHANG Ai-jun，SHEN Ji-hong.

    First Institute of Oceanography，SOA，Qingdao266061，China

    【Abstract】 Objective To evaluate biologic security for grape procyanidins.Methods The mouse acute toxicity test and heredity toxicity test of grape procyanidins were ivestigated.Results It was shown that all tests of acute and heredity toxicity were negative.The study of rats on30days feeding showed that the experimental groups had been in good state，and the body weight，food intake，haematological profile，viscera modulus had been in ordinary scope.There were no significant difference between test group and control group(P>0.05).Conclusion Results from this study indicate a lack of toxicity for grape procyanidins.

    【Key words】 grape procyanidins;toxicologicaly

    葡萄多酚(Grape Proanthocyanidins ......