【摘要】 目的 探讨1.34%强化妥布霉素滴眼液治疗绿脓杆菌性角膜溃疡的方法和疗效。方法 26例(26眼)随机分成两组，每组13例(13眼)。强化浓度组(A组)：1.34%妥布霉素滴眼液滴眼；对照组(B组)0.3%妥布霉素滴眼液滴眼。两组均接受全身加局部同种和相同剂量的抗生素及激素治疗。分别观察两组角膜溃疡局限、前房积脓吸收、角膜水肿消退平均时间、病原菌培养结果和治愈后1个月最佳矫正视力，统计学处理采用t检验。结果 两组病例角膜溃疡均得到控制，所有病例均得以保留眼球，视力得到不同程度改善。强化治疗组角膜溃疡局限、前房积脓吸收时间短于对照组，经统计学分析差异有显著性。两组病原菌培养结果和治愈后1个月最佳矫正视力分布差异经统计学分析差异无显著性。结论 妥布霉素滴眼液为治疗绿脓杆菌性角膜溃疡的一线药物，强化妥布霉素频繁点眼可以快速达到较高组织浓度，加快角膜溃疡愈合过程，是有效而且安全的治疗方法。

    【关键词】 绿脓杆菌性角膜溃疡；妥布霉素；浓度Tobramycin in treatment of pseudomonas aeruginosa corneal ulcer

    ZHONG Guang-bin,CHEN Yao-ruo.

    The People’s Hospital of Dongguan,Dongguan 523018,China

    【Abstract】 Objective To discuss the use and effect of 1.34% tobramycin eyedrop in the treatment of pseudomonas aeruginosa corneal ulcer.Methods 26 patients (26 eyes in 26 cases) were randomized into two groups:1.34% tobramycin eyedrop (group A),13 eyes,0.3% tobramycin eyedrop,13 eyes (group B).All the 26 cases received same systemic and topical antibiotic administration.The treatments of two groups were analysed in a retrospective manner.Results All the 26 eyes were saved from corneal ulcer.The inflammatory exudation in anterior chamber aqueous was absorbed quicker in group A,as compared with that in group B.Conclusion 1.34% tobramycin eyedrop is one of the effective and safe topical antibiotic administration in the treatment of pseudomonas aeruginosa corneal ulcer. ......