【摘要】 目的 探讨氯沙坦短期治疗对伴有高尿酸血症的冠心病患者血尿酸(UA)的影响。方法 随机选取血尿酸水平高于正常的60例冠心病患者，分别服用氯沙坦和福辛普利，用尿酸酶终点法检测治疗前后血尿酸(UA)的水平。结果 用氯沙坦治疗后血浆中尿酸浓度[(354.6±71.2)μmol/L]较治疗前[(488.4±68.3)μmol/L]显著下降(P<0.001)；用福辛普利治疗后[(401.7±67.5)μmol/L]较治疗前[(436.8±89.4)μmol/L]无明显变化(P>0.05)；两组治疗后比较有统计学意义(P<0.05)。结论 氯沙坦可以显著降低伴有高尿酸血症的冠心病患者UA水平，从而减少冠心病的危险因素。

    【关键词】 氯沙坦；高尿酸血症；冠心病；尿酸

    Effect of losartan on serum uric acid in patients with coronary heart disease with hyperuricemia

    ZHOU Quan,WANG Li-mei.Department of Cardiology,The Third Central Hospital,Tianjin 300170,China

    【Abstract】 Objective To investigate the effect of losartan on serum uric acid(UA) in patients of coromary heart disease with hyperuricemia.Methods The levels of serum uric acid were determined by uricase terminal pointed assay in 60 cases of coronary heart disease with hyperuricemia.They were treated by losaran or fosinopril.Results The levels of serum uric acid in the patients who were treated by losaran for 2 weeks significantly decreased than before.[(354.6±71.2)μmol/L] VS [(488.4±68.3)μmol/L].(P<0.001).The levels of serum uric acid in the patients who were treated by fosinopril for 2 weeks unsignificantly decreased than before.[(401.7±67.5)μmol/L] VS [(436.8±89.4)μmol/L].(P>0.05).Conclusion The result show that losartan may play a important role of decreasing the level of uric acid in patient of coronary heart disease with hyperuricemia,then reducing the drisk factors about coronary heart disease. ......