【摘要】 目的 监测上海市区级及社区医院耐甲氧西林金葡菌及耐甲氧西林凝固酶阴性葡萄球菌的流行及耐药现状。方法 对二所区级及社区医院从2003年8月～2004年2月的感染标本中分离的378株葡萄球菌进行鉴定和药敏实验。结果 对耐甲氧西林金葡菌分离率52.38%，对耐甲氧西林凝固酶阴性葡萄球菌分离率47.62%。二者均为多重耐药球菌，但对利福平均敏感，耐药率分别为0.9%及2.9%。二者均未发现耐万古霉素菌株。结论 上海市二所社区医院中耐甲氧西林金葡菌及耐甲氧西林凝固酶阴性葡萄球菌的流行是严重的，其中前者的流行显著高于教学医院，二者均为多重耐药菌株。

    【关键词】 耐甲氧西林金葡菌；耐甲氧西林凝固酶阴性葡萄球菌；耐药性；流行病学

    Monitor of two kinds of methicillin resistance staphylococcus

    WEI Shan-mei,XU Nai-chang.

    Department of Medicine,Shanghai Longhua Local Hospital,Shanghai 200032,China

    【Abstract】 Objective To investigate the prevelance of methicillin resistance staphylococcus aureus(MRSA) and methicillin resistance coagulase-negative staphylococci(MRCNS) at present situation in Shanghai district hospitals.Methods Isolates of staphylococci(378) were collected from infections samples in two district hospitals were identified and the susceptibility test were performed from Augest 2003 to February 2004.Results The rate of MRSA and MRCNS were 52.3% and 47.6%,respectively.Both of them were multi-resistance to eight antibiotics,but the resistant rate to rifanpicin were 0.9% and 2.9% respectievly.No vancomycin resistant strains were found.Conclusion The prevalence of MRSA and MRCNS in two district hospitals in Shanghai were serious,and MRSA was more serious than the major hospitals at home.Both of them were multi-resistance to antibiotics. ......