【摘要】 目的 通过观察分析呼吸机相关性肺炎(VAP)患者的临床资料，提高对VAP的认识。方法 收集1996年1月～2004年12月VAP患者临床资料，对VAP发病时间、病原菌、抗生素敏感性及VAP患者转归加以分析。结果 VAP的发生与机械通气时间呈正相关，随通气时间延长，病死率极高。VAP主要病原菌为铜绿假单胞菌、不动杆菌、金黄色葡萄球菌、真菌。有多重耐药趋势。结论 VAP治疗较困难，病死率极高。加强预防可能是控制该病流行，降低病死率的最重要措施。

    关键词 肺炎 呼吸 临床资料 危险因素

    Clinical observation and analysis of 42 VAP cases

    Wei Songhua,Yu Hong

    Department of Respiration ,The 10th People’s Hospital Affiliated to Tongji University,Shanghai 200072.

    【Abstract】 Objective To further study our recognizition of VAP through the clinical observation and anlysis.Methods The clinical data of VAP (Jan.1996～Dec.2004),especially the time of occurrence,the pathogenic microorganisms,the sensibility of antibiotics and the outcomes of VAP were analyzed.Results The occurrence of VAP was positively correlated with the mechanical ventilated time.The longer time of ventilation,the greater the case-fatality rate.The principal pathogenic microorganisms were pseudomonas,immovable bacillus,staphylococcus aureus and fungi.The pathogenic microorganisms had mutiple drug resistance tendency.Conclusion VAP is comparatively hard to cure,and its case-fatality rate is extraordinarily high.Augmentation of prevention is probably the most effective measure in the control of its prevalence and the decrease of its case-fatality rate. ......