【摘要】 目的 研究低分子肝素、苯那普利联合治疗对早期糖尿病肾病患者微量白蛋白尿的效果。方法 早期糖尿病肾病患者80例，随机分为对照组、苯那普利治疗组、低分子肝素治疗组及联合治疗组，分别测定治疗前及治疗后0、4、8、12周空腹血糖(FBG)、餐后2h血糖(PBG)、尿白蛋白排泄率(AER)、血肌酐(Cr)等。结果 对照组随观察时间延长，AER略升高，但差异无显著性(P>0.05)，苯那普利组、低分子肝素组治疗后4、8、12周AER均低于同期对照组水平(P<0.05)，联合治疗组明显低于同期对照组水平(P<0.01)，治疗后联合治疗组较同期低分子肝素组或苯那普利组也差异显著(P<0.05)。结论 低分子肝素与苯那普利联合治疗早期糖尿病肾病，可明显减少尿白蛋白排泄，保护肾功能，较单一用药效果显著。

    关键词 糖尿病肾病 苯那普利 低分子肝素 白蛋白尿

    Effect of low molecular weight heparin and benazepril in treatment of early diabetic nephropathy with microalbuminuria

    Li Qiong，Gong Xiongwei

    Guangdong Gaozhou People’s Hospital，Gaozhou 525200.

    【Abstract】 Objective To study the effect of low molecular weight heparin(LMWH)and benazepril in decreasing the urinary albumin execretion rate(AER)in early diabetic nephropathy.Methods 80 diabetic patients with AER between 20μg/min and 200μg/min were divided randomly into four groups:the control group,LMWH-treated group,benazepril-treated group and unite-treated group.FBG、PBG、AER and blood creatinine(Cr)were examined immediately and 4,8,12 weeks after the treatment.Results In the control group,AER was increased lightly after 4,8,12 weeks than at beginning,but there was no difference(P>0.05).In LMWH-treated group and benazepril-treated group ......