【摘要】 目的 探讨对伴有代谢综合征(MS)的2型糖尿病(T2DM)患者早期多环节联合治疗的效果。方法 对92例无动脉粥样硬化(AS)伴MS的T2DM(病程不超过1年)患者，给予强化控制血糖、血压、血脂及抗血小板聚集的多环节联合治疗，随访1年观察MS各成分的变化。结果 早期多环节联合治疗随访1年伴代谢综合征的2型糖尿病患者体质指数(BMI)、糖化血红蛋白(HbA1C)、甘油三酯(TG)、收缩压(SBP)及舒张压(DBP)、胰岛素抵抗指数(HOMA-IR)、颈总动脉(CCA)及股动脉(FA)内中膜厚度(IMT)均下降(P<0.05)；胰岛细胞分泌功能指数(HOMAB-cell index)上升(P<0.05),57.6%(53/92)患者转变为无MS患者，89.1%(82/92)患者减少至少一项MS组分。结论 早期多环节联合治疗伴代谢综合征的2型糖尿病患者，有助于改善MS的各项指标。

    关键词 代谢综合征 2型糖尿病 早期联合治疗

    Exploration of the effects of the multilink combined therapy to type 2 diabetics with metabolic syndrome at the early stage

    Li Yudong,Zhang Peiyun, Hua Yinong

    Shanghai South-east Hospital,Shanghai 200023.

    【Abstract】 Objective To explore the effects of the multilink combined therapy at the early stage to diabetics with metabolic syndrome(MS).Methods 92 diabetic patients without atherosclerosis(AS) were designed to carry on the multilink combined therapy,including the control of blood glucose,blood pressure,blood lipid,and meanwhile these patients were given asprin treatment.The MS components were examined after 1-year combined therapy.Results The levels of metabolic parameters such as HbA1C,TG,SBP anf DBP,HOMA-IR,HOMAβ-cell index,intimal media thickness of common carotid artery and femoral artery were significantly improved after one-year combined therapy(P<0.05).57.6%(53/92)patients with MS changed to the stage without MS.MS components in 89.1%(82/92)patients reduced at least one component.Conclusion MS severity could be improved after multilink combined therapy at the early stage. ......