【摘要】 目的 进一步提高新生儿重症感染的早期诊断率，探讨一种快速、可靠的方法。 方法 用LUMI Test PCT方法检测在我院出生的有感染可能的新生儿的脐动脉血清降钙素原(PCT)。同时检测脐动脉血C反应蛋白(CRP);由新生儿专业的医师对其病情进行观察，在不知道PCT值时做出病情临床诊断;病例组58例分为:重症感染组(23例)和局部感染组(35例)，与对照组正常足月新生儿(30例)进行回顾性对比分析。 结果 早期开始的新生儿感染与CRP和PCT浓度在出生时的增加有显著相关性(P<0.001);脐动脉血中，PCT浓度的增加与CRP水平变化呈正相关(r=0.86)。PCT的敏感性(95.6%)和特异性(97.1%)均高于CRP(敏感性78.3%，特异性94.2%)。 结论 PCT可作为新生儿感染的早期、快速检测指标，与CRP相比，PCT敏感性、特异性均高。本研究方法对新生儿无创伤。

    关键词 新生儿 早期感染 降钙素原 脐动脉

    Study on the correlation between early-onset neonatal infection and the level of plasma PCT in umbilical artery

    Gao Yan，Yang Jinhua，Yang Quanqing，et al.

    Maternal and Infant Health Hospital of Lianyungang，Jiangsu222000.

    【Abstract】 Objective To investigate the early and reliable diagnostic method and clinic significance of pro-calatonin(PCT)in neonates with early-onset infection.Methods The level of plasma PCT in umbilical artery and plasma C-reaction protein(CRP)were determined by immunoluminometric assay in58neonates with suspected infec-tion.The attending neonatologists from our hospital performed all care.Designation of infection status had to be made retrospectively because all neonates were considered at risk for ......