【摘要】 目的 探讨帕金森病伴发抑郁症相关因素及发病机制。 方法 收集门诊及住院的帕金森病患者共200例进行抑郁自评量表(SDS)、HAMD量表及自制一般情况调查表的评定，对相关因素进行分析。对抑郁患者行氟西汀治疗，计算治疗有效率。 结果 200例患者中出现抑郁症状66例，占33.0%。伴发抑郁相关因素为:年龄、受教育程度、肌强直及病程。年龄越小、受教育程度越高、病程长及肌强直明显者抑郁的患病率越高。氟西汀对帕金森伴发抑郁症治疗，有效率为36.4%。 结论 帕金森病伴发抑郁的相关因素复杂，抑郁的发生可能是反应性的，也可能是内源性的。氟西汀治疗有效。

    关键词 帕金森病 抑郁

    A study of related factors of depression after Parkinson's disease

    Chi Kemei，Zhao Liu Zhuang，Yu Huafeng，et al.

    Department of Neurology，Tongren Hospital，Beijing，100730.

    【Abstract】 Objective To investigate the related factors of depression after Parkinson's disease(PD)and dis-cuss the pathogenesis.Methods 200patients with PD were assessed by Hamiton Depression Rating Scales(HAMD)，Selt-Rating Depression Scale(SDS)，a self-designed question.Related factors were analyzed.Results 66cases(33.0%)were identified as suffering from depression.Age、educational level、course of disease and symptom are relat-ed factors.The younger、higher education level、longer course of disease and more obvious tonus ......