白术对肝硬化大鼠胃动力和氮能神经分布的影响及意义
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朱金照, 许其增, 张志坚, 乐桥良
白术;胃动力;氮能神经;肝硬化;大鼠,朱金照,许其增,张志坚,乐桥良,通讯作者,:,EffectsofAtractylodesmacrocepha
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朱金照,许其增,张志坚, 乐桥良, 中国人民解放军南京军区福州总医院消化内科 福建省福州市 350025
朱金照,男,1964-01-28生,江西省莲花县人,汉族,2000年第三军医大学医学硕士,主要从事胃肠动力疾病及中药促胃肠动力作用的研究.
通讯作者:朱金照,350025, 福建省福州市西环北路156号,中国人民解放军南京军区福州总医院消化内科中心.
电话: 0591-83727698
收稿日期:2005-03-25 接受日期:2005-04-20
Effects of Atractylodes macrocephalae on gastric emptying and nitrergicnerves in rats with hepatic cirrhosis
Jin-Zhao Zhu, Qi-Zeng Xu, Zhi-Jian Zhang, Qiao-Liang Le
Jin-Zhao Zhu, Zhi-Jian Zhang, Qi-Zeng Xu, Qiao-Liang Le, Departmentof Gastroenterology, Fuzhou General Hospital of Nanjing Military Command,Fuzhou 350025, Fujian Province, China
Correspondence to: Jin-Zhao Zhu, Department of Gastroenterology,FuZhou General Hospital of Nanjing Military Command, 156 Xihuan NorthRoad, Fuzhou 350025, Fujian Province, China.
Received: 2005-03-25 Accepted:2005-04-20
Abstract
AIM: To observe the effects of atractylodes macrocephalae (AM) ongastric motility and nitrergic nerval system in rats with hepaticcirrhosis.
METHODS: Twenty-four Wister rats were randomly divided into controlgroup, cirrhosis model group and AM treatment group. Dextran blue-2000 wasused as an internal marker to assay the gastric emptying of the rats. Thenitrergic nerves in the myenteric plexuses of gastric fundus, body andantrum were observed with NADPH-d histochemical staining.
RESULTS: Compared with those in control group, the gastric emptyingsof rats were markedly delayed in model group (160.23±45.13 vs100±17.78,P<0.01), and the distributions and densities of myentericnitrergic nerves in the gastric body and antrum were significantlyincreased (7.35±0.95vs 5.52±0.92,P<0.01; 6.26±0.79vs 5.28±0 ......
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