GABA对小鼠回肠平滑肌自主收缩活动的影响
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田 琴, 胡还忠, 马立群, 汪长东, 王晓敏,
GABA;NO;b受体;平滑肌;回肠,田琴,胡还忠,马立群,汪长东,王晓敏,梁华敏,田琴,通讯作者,:,Effectof,g,-aminobutyric
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田琴, 胡还忠,马立群, 汪长东, 王晓敏,梁华敏,华中科技大学同济医学院生理系 湖北省武汉市 430030
田琴, 女,1980-10-19生,湖北省恩施人,土家族,华中科技大学同济医学院生理学硕士,主要从事消化生理方面的研究.
通讯作者:胡还忠,430030, 湖北省武汉市,华中科技大学同济医学院生理系. huhuanzh@163.com
电话: 027-83630850
收稿日期:2005-06-06 接受日期:2005-06-13
Effect of g-aminobutyricacid on spontaneous contraction of ileum smooth muscle in mice
Qin Tian, Huan-Zhong Hu, Li-Qun Ma, Chang-Dong Wang, Xiao-Min Wang, Hua-MinLiang
Qin Tian, Huan-Zhong Hu, Li-Qun Ma, Chang-Dong Wang, Xiao-Min Wang, Hua-MinLiang, Department of Physiology, Tongji Medical College, HuazhongUniversity of Science and Technology, Wuhan 430030, Hubei Province, China
Correspondence to: Huan-Zhong Hu, Department of Physiology, TongjiMedical College, Huazhong University of Science and Technology, Wuhan430030, Hubei Province, China. huhuanzh@163.com
Received: 2005-06-06 Accepted: 2005-06-13
Abstract
AIM: To investigate the effects of g-aminobutyricacid (GABA) on the spontaneous contraction of mouse ileac smooth muscleand the interactions between GABA and b-receptorand nitric oxide (NO).
METHODS: The contraction changes of the isolated smooth musclestripswere recorded by tension transducer, and the change of the tensionwas used as the marker to evaluate the effects of GABA. The effects of ODQ,L-NNA, propranolol on the action of GABA were also analyzed. .
RESULTS: GABA inhibited the spontaneous contraction of mouse ileumat the concentrations ranging from 1×10-6to 1×10-3mol/L. The contraction amplitudes were decreased by (34.71±7.35)%and (22.23±4.69)%,respectively, when 1×10-6and 1×10-3mol/L GABA were used. Picrotoxin showed no significant effect on theinhibitory actions caused by GABA ......
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