【摘要】 目的 评价大剂量利血生片治疗白细胞减少症的临床疗效和安全性。方法 将70例抗甲亢药物引起的白细胞减少症患者随机分为3组：A组30例，口服大剂量利血生片40mg/次，每日3次；B组30例，口服常规剂量利血生片20mg/次，每日3次；C组(安慰剂组)10例，口服维生素B1片20mg/次，每日3次。疗程均为4周,观察治疗前后白细胞计数的变化和不良反应，并进行组间疗效对比。结果 A组显效16例，有效10例，无效4例，总有效率为87%；B组显效9例，有效12例，无效9例，总有效率为70%。 两组总有效率均明显高于安慰剂组(20%，P<0.01)，但A组优于B组(P<0.05)。在治疗过程中未发现利血生片有任何毒副作用。结论 大剂量利血生片治疗白细胞减少症,疗效优于常规剂量且安全。

    【关键词】 白细胞减少症；利血生片

    Effectiveness and safety of large dose of leucogen tablets in treating leukopenia

    GAO Feng，HU Xiu-fen.

    Department of Endocrinology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China

    【Abstract】 Objective To evaluate the effectiveness and safety of large dose of leucogen tablets in treating leukopenia.Methods 70 patients with leukopenia resulted from anti-thyroid drugs were randomized into 3 groups.30 cases in Group A took orally leucogen tablets at the dose of 40mg tid.Another 30 cases in Group B were treated with conventional dose (20mg tid) of leucogen tablets.The rest 10 cases given vitamin B1 (20mg tid) were enrolled into Group C (placebo group).All the patients were treated for 4 weeks.Before and after the treatment the change of peripheral leucocytes count and adverse effects were investigated and the efficacy was compared among 3 groups.Results In Group A the apparent efficiency was achieved in 16 cases,efficiency in 10 cases but no effect in 4 cases,giving rise to 87% of total efficiency rate.Whereas,in Group B,the apparent efficiency was seen in 9 cases,efficiency in 12 cases but no effect in 9 cases,generating 70% of total efficiency rate.The total efficiency rate in either Group A or Group B was significantly higher than that in placebo group (20%,P<0.01).But the effect in Group A was superior to that in Group B (P<0.05).There were no side effects found during leucogen treatment.Conclusion In the treatment of leukopenia,large dose of leucogen tablets is superior to conventional dose,with satisfying effectiveness and good tolerance. ......