恶性消化道肿瘤晚期患者血TNF-α与胰岛素抵抗和胰岛素分泌的功能关系
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冯青青，王占科，吕小林，刘亚诚，余 文，涂 云
消化道肿瘤;TNF-α;胰岛素抵抗;胰岛素分泌;糖代谢;乳酸,冯青青，王占科，余文，涂云，,吕小林，,刘亚诚，,通讯作者：,Rel
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冯青青，王占科，余文，涂云，解放军第九四医院 江西省南昌市 330002
吕小林，江西医学院第一附属医院 江西省南昌市 330006
刘亚诚，江西省人民医院 江西省南昌市 330006
通讯作者：冯青青，330002，江西省南昌市，解放军第九四医院.
收稿日期：2005-07-19 接受日期：2005-07-28
Relations of plasma TNF-α with insulin resistance and insulin excretion in terminal patients with malignant gastrointestinal tumor
Qing-Qing Feng, Zhan-Ke Wang, Xiao-Lin Lv, Ya-Cheng Liu, Wen Yu, Yun Tu
Qing-Qing Feng, Zhan-Ke Wang, Wen Yu, Yun Tu, the 94th Hospital of Chinese PLA, Nanchang 330002, Jiangxi Province, China
Xiao-Ling Lv, the First Affiliated Hospital of Jiangxi Medical College, Nanchang 330002, Jiangxi Province, China
Ya-Cheng Liu, the People’s Hospital of Jiangxi, Nanchang 330002, Jiangxi Province, China
Correspondence to: Qing-Qing Feng, the 94th Hospital of Chinese PLA, Nanchang 330002, Jiangxi Province, China
Received: 2005-07-19 Accepted: 2005-07-28
Abstract
AIM: To explore the relations of plasma TNF-α with insulin resistance and insulin excretion in the disorder of glucose metabolism in the terminal patients with enteron malignant tumor.
METHODS: The levels of the fasting glucose, insulin, lactic acid, postprandial glucose, lactic acid were measured in 40 terminal patients with enteron malignant tumor as well as in 40 normal controls, and the homeostasis model assessment of insulin resistance (HOMA-IR) and HOMA-β were calculated.
RESULTS: The levels of the plasma TNF-α, the fasting glucose, insulin and lactic acid, and the values of HOMA-IR and HOMA-β in the terminal patients with enteron malignant tumor were significantly higher than those in the controls (3.27±0.92 vs 1.23±0.36, P <0.01; 5.19±0.75 vs 4.05±0.28, P <0.01; 14.24±6.52 vs 8.27±4.84, P <0.01; 7.11±0.69 vs 3.27±0.41, P <0.01; 3.48±0.85 vs 1.55±0.77, P <0.01; 181±39 vs 326±47, P <0.01), but the content of the fasting glucose was in normal range. The level of the plasma TNF-α was positively correlated with the contents of the fasting glucose, insulin and lactic acid and the value of HOMA-IR (r = 0.4352, P <0.05; r = 0.3136, P <0.05; r = 0.7893, P <0.01; r = 0.6531, P <0.01), but negatively correlated with the value of HOMA-β in terminal patients with enteron malignant tumor (r = -0.5874, P <0.01).
CONCLUSION: The plasm TNF-α plays an important role in the insulin resistance, the hyposecretion of insulin and the disorder of glucose-metabolism in the terminal patients with malignant gastrointestinal tumor.
Key Words: Malignant gastrointestinal tumor; TNF-α; Insulin resistance; Insulin excretion; Glucose-metabolism; Lactic acid
Feng QQ, Wang ZK, Lv XL, Liu YC, Yu W, Tu Y. Relationship between plasma TNFα and Insulin resistance, Insulin excretion in terminal patients with enteron malignant tumor. Shijie Huaren Xiaohua Zazhi 2005;13(17):2150-2153
摘要
目的：证明恶性消化道肿瘤晚期患者血浆肿瘤坏死因子α(TNF-α)与胰岛素抵抗和胰岛素分泌功能相关性 ......
冯青青，王占科，余文，涂云，解放军第九四医院 江西省南昌市 330002
吕小林，江西医学院第一附属医院 江西省南昌市 330006
刘亚诚，江西省人民医院 江西省南昌市 330006
通讯作者：冯青青，330002，江西省南昌市，解放军第九四医院.
收稿日期：2005-07-19 接受日期：2005-07-28
Relations of plasma TNF-α with insulin resistance and insulin excretion in terminal patients with malignant gastrointestinal tumor
Qing-Qing Feng, Zhan-Ke Wang, Xiao-Lin Lv, Ya-Cheng Liu, Wen Yu, Yun Tu
Qing-Qing Feng, Zhan-Ke Wang, Wen Yu, Yun Tu, the 94th Hospital of Chinese PLA, Nanchang 330002, Jiangxi Province, China
Xiao-Ling Lv, the First Affiliated Hospital of Jiangxi Medical College, Nanchang 330002, Jiangxi Province, China
Ya-Cheng Liu, the People’s Hospital of Jiangxi, Nanchang 330002, Jiangxi Province, China
Correspondence to: Qing-Qing Feng, the 94th Hospital of Chinese PLA, Nanchang 330002, Jiangxi Province, China
Received: 2005-07-19 Accepted: 2005-07-28
Abstract
AIM: To explore the relations of plasma TNF-α with insulin resistance and insulin excretion in the disorder of glucose metabolism in the terminal patients with enteron malignant tumor.
METHODS: The levels of the fasting glucose, insulin, lactic acid, postprandial glucose, lactic acid were measured in 40 terminal patients with enteron malignant tumor as well as in 40 normal controls, and the homeostasis model assessment of insulin resistance (HOMA-IR) and HOMA-β were calculated.
RESULTS: The levels of the plasma TNF-α, the fasting glucose, insulin and lactic acid, and the values of HOMA-IR and HOMA-β in the terminal patients with enteron malignant tumor were significantly higher than those in the controls (3.27±0.92 vs 1.23±0.36, P <0.01; 5.19±0.75 vs 4.05±0.28, P <0.01; 14.24±6.52 vs 8.27±4.84, P <0.01; 7.11±0.69 vs 3.27±0.41, P <0.01; 3.48±0.85 vs 1.55±0.77, P <0.01; 181±39 vs 326±47, P <0.01), but the content of the fasting glucose was in normal range. The level of the plasma TNF-α was positively correlated with the contents of the fasting glucose, insulin and lactic acid and the value of HOMA-IR (r = 0.4352, P <0.05; r = 0.3136, P <0.05; r = 0.7893, P <0.01; r = 0.6531, P <0.01), but negatively correlated with the value of HOMA-β in terminal patients with enteron malignant tumor (r = -0.5874, P <0.01).
CONCLUSION: The plasm TNF-α plays an important role in the insulin resistance, the hyposecretion of insulin and the disorder of glucose-metabolism in the terminal patients with malignant gastrointestinal tumor.
Key Words: Malignant gastrointestinal tumor; TNF-α; Insulin resistance; Insulin excretion; Glucose-metabolism; Lactic acid
Feng QQ, Wang ZK, Lv XL, Liu YC, Yu W, Tu Y. Relationship between plasma TNFα and Insulin resistance, Insulin excretion in terminal patients with enteron malignant tumor. Shijie Huaren Xiaohua Zazhi 2005;13(17):2150-2153
摘要
目的：证明恶性消化道肿瘤晚期患者血浆肿瘤坏死因子α(TNF-α)与胰岛素抵抗和胰岛素分泌功能相关性 ......
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