乙肝疫苗联合含CpG基序寡脱氧核苷酸和卡介苗对小鼠的免疫应答影响
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王 甦, 陈 群, 王 兴, 张 燕, 马 丽,
CpGODN;卡介苗;乙肝疫苗;乙肝表面抗体;CD4+;CD8+,王甦，王兴，张燕，,陈群，,马丽，汪中强，,王甦，,通讯作者：,Ef
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王甦，王兴，张燕，扬州大学医学院附属医院传染科 江苏省扬州市 225001
陈群， 扬州大学医学院形态学教研室 江苏省扬州市 225001
马丽，汪中强，扬州大学医学院附院血液科 江苏省扬州市 225001
王甦，男，1965-02-05生，泰州市姜堰市人，汉族，2003年四川大学华西临床医学院医学博士，副主任医师，主要从事病毒性肝 炎的研究.
扬州大学自然科学资金资助项目
江苏省扬州市卫生局资助项目，No. K0111237
通讯作者：陈群，225001，江苏省扬州市淮海路11号，扬州大学医学院形态学教研室.
收稿日期：2005-05-28 接受日期：2005-06-13
Effect of hepatitis B vaccine with CpG oligodeoxynucleotide or Bacilli Calmette Guerin on immune responses in mice
Su Wang, Qun Chen, Xing Wang, Yan Zhang, Li Ma, Zhong-Qiang Wang
Su Wang, Xing Wang, Yan Zhang, Department of Infection Diseases of Medical Collage, Yangzhou University, Yangzhou 225001, Jiangsu Province, China
Qun Chen, Department of Morphology of Medical Collage, Yangzhou University, Yangzhou 225001, Jiangsu Province, China
Li Ma, Zhong-Qiang Wang, Department of Blood Disease of Medical Collage, Yangzhou University, Yangzhou 225001, Jiangsu Province, China
Supported by the Natural Science Foundation of Yangzhou University, and the Fund from Health Administration of Yangzhou, Jiangsu Province, No. K0111237
Correspondence to: Qun Chen, Department of Morphology of Medical Collage, Yangzhou University, Yangzhou 225001, Jiangsu Province, China
Received: 2005-05-28 Accepted: 2005-06-13
Abstract
AIM: To investigate the effects of hepatitis B vaccine with CpG oligodeoxynucleotide (ODN) or Bacilli Calmette Guerin on the immune responses in mice.
METHODS: BALB/c mice were subcutaneously injected with different doses of hepatitis B vaccine (0.25, 0.75, 1.0 μg) combined with CpG ODN or BCG. The levels of serum hepatitis surface antibody (anti-HBs) were detected by ELISA assays two and four weeks after injection. The changes of peripheral blood T lymphocyte subsets CD4+, CD8+ and CD4+/CD8+ ratio were detected by flow cytometry ......
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