荔枝核总黄酮的抗鸭乙型肝炎病毒作用
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徐 庆, 宋芸娟, 李丽亚, 侯巧燕
荔枝核总黄酮;抗乙肝病毒;鸭乙肝模型,徐庆，李丽亚，侯巧燕，,宋芸娟，,徐庆，,EffectoftotalflavoneofLitchiChinensisSonno
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徐庆，李丽亚，侯巧燕，桂林医学院药理教研室 广西壮族自治区桂林市 541004
宋芸娟，广西药用植物园 广西壮族自治区南宁市 530023
徐庆，男，1956年生，汉族，山东省胶州市人，1990年广西中医学院硕士, 教授，主要从事抗病毒抗肿瘤天然药物研究.
广西科学研究与技术开发计划项目(桂科能)，No. 0330015-4C
通讯作者：徐庆，541004，广西壮族自治区桂林市，桂林医学院药理教研室. xq5895801@163.com
电话：0773-5895801
收稿日期：2005-06-28 接受日期：2005-07-08
Effect of total flavone of Litchi Chinensis Sonn on duck hepatitis B virus
Qing Xu, Yun-Juan Song, Li-Ya Li, Qiao-Yan Hou
Qing Xu, Li-Ya Li, Qiao-Yan Hou, Department of Pharmacology, Guilin Medical College, Guilin 541004, Guangxi Zhuang Autonomous Region, China
Yun-Juan Song, Medicinal Garden of Guangxi, Nanning 530023, Guangxi Zhuang Autonomous Region, China
Supported by the Science and Technology Plan of Guangxi Zhuang Autonomous Region, No. 0330015-4C
Correspondence to: Qing Xu, Department of Pharmacology, Guilin Medical College, Guilin 541004, Guangxi Zhuang Autonomous Region, China. xq5895801@163.com
Received: 2005-06-28 Accepted: 2005-07-08
Abstract
AIM: To study the anti-duck hepatitis B virus (DHBV) action of the total flavone of Litchi Chinensis Sonn (TFL).
METHODS: Guilin ducklings with congenital infection of DHBV were used as the animal modal. TFL was orally given to the ducks with the doses 2 g/(kg•d) and 1 g/(kg•d) for 15 days. The expression of DHBV DNA was detected by spot blot hybridization before and after TFL was given. The pathological changes of the duck liver were also examined by HE staining.
RESULTS: TFL at the dose of 2 g/(kg•d) can lower the level of serum DHBV DNA significantly (vs control group: 0.74±0.42 vs 1.64±0.68, P <0.05) 15 days after treatment. No marked necrosis was observed in the liver of high dose group (0/6), but 4 of 6 cases appeared obvious necrosis in control group after treatment. There was significant difference between them (P <0 ......
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