肝硬化患者糖代谢变化临床分析46例
http://www.100md.com
罗庆锋, 许 乐, 傅 亮
肝硬化;糖代谢;胰岛素,罗庆锋，许乐，傅亮，,通讯作者：,Changesofglucosemetabolisminpatientswithlivercirrhosi
参见附件(1kb)。
罗庆锋，许乐，傅亮，卫生部北京医院消化内科 北京市 100730
通讯作者：罗庆锋，100730，北京市东单大华路1号，北京医院消化内科. luoqf2000@sohu.com
电话：010-65132266-6142
收稿日期：2005-08-01 接受日期：2005-08-20
Changes of glucose metabolism in patients with liver cirrhosis: an analysis of 46 cases
Qing-Feng Luo, Le Xu, Liang Fu
Qing-Feng Luo, Le Xu, Liang Fu, Department of Gastroenterology, Beijing Hospital, Beijing 100730, China
Correspondence to: Qing-Feng Luo, Department of Gastroenterology, Beijing Hospital, 1 Dongdan Dahua Road, Beijing 100730, China. luoqf2000@sohu.com
Received: 2005-08-01 Accepted: 2005-08-20
Abstract
AIM: To investigate the changes of glucose metabolism and the possible mechanism.
METHODS: The levels of plasma glucose, insulin and C-peptide were measured in 46 patients with liver cirrhosis and 25 healthy people before (fasting) and 2 h after the oral glucose tolerance test (OGTT). The insulin sensitivity index (ISI) was calculated. All the results were analyzed comparatively.
RESULTS: In patients with liver cirrhosis, the levels of fasting plasma glucose and C-peptide were 5.58±2.14 mmol/L and 593±156 pmol/L, respectively (P >0.05); 2 h after OGTT, the levels of plasma glucose and C-peptide were 11.97±4.20 mmol/L and 3411±964 pmol/L, respectively, which were significantly higher than those in the healthy controls (P <0.05). In the liver cirrhosis patients, the levels of plasma insulin before (fasting) and 2 h after the OGTT were 12.23±5.4 mU/L and 105.16±40.70 mU/L, respectively, which were significantly higher than those in the healthy controls (P <0.05). The value of ISI in liver cirrhosis patients was significantly lower than that in the healthy controls (1.47±0.54 vs 2.73±0.62, P <0.05).
CONCLUSION: Abnormal glucose metabolism exists in patients with liver cirrhosis, and its mechanism may be related to the insulin resistance.
Key Words: Liver cirrhosis; Glucose metabolism; Insulin
Luo QF, Xu L, Fu L. Changes of glucose metabolism in patients with liver cirrhosis: an analysis of 46 cases. Shijie Huaren Xiaohua Zazhi 2005;13(17):2162-2164
摘要
目的：探讨肝硬化患者糖代谢变化及其可能的致病机制.
方法：对46例肝硬化患者及25例正常人分别测定空腹及口服75 g葡萄糖耐量试验(oral glucose tolerance test，OGTT)2 h后的血糖、血浆胰岛素及C肽水平，计算胰岛素敏感指数(insulin sensitivity index，ISI)，并对各项结果进行比较分析.
结果：肝硬化组空腹血糖、C肽水平分别为5.58±2.14 mmol/L、593±156 pmol/L，较对照组差异均没有显著性意义(P>0.05)；OGTT 2 h后血糖、C肽水平分别为：11.97±4.20 mmol/L、3411±964 pmol/L，均明显高于对照组(P<0.05)；而胰岛素测定结果可见肝硬化患者空腹及OGTT 2 h后胰岛素水平分别为：12.23±5.4 mU/L、105.16±40.70 mU/L，均明显高于对照组；肝硬化组ISI显著低于对照组(1.47±0.54vs 2.73±0.62，P<0.05).
结论：肝硬化患者存在明显的糖代谢异常，这种糖代谢异常与胰岛素抵抗有关.
关键词：肝硬化；糖代谢；胰岛素
罗庆锋，许乐，傅亮.肝硬化患者糖代谢变化临床分析46例. 世界华人消化杂志 2005;13(17):2162-2164
0 引言
肝脏对体内葡萄糖的代谢起着重要的调节作用，是维持血糖稳定的重要器官.而肝硬化是累及全身各脏器的慢性疾病.肝硬化患者合并糖尿病是影响生存期的一个危险因素，患者有较高的死亡率[4,8].为了探讨肝硬化患者糖代谢变化及其可能的发病机制 ......
罗庆锋，许乐，傅亮，卫生部北京医院消化内科 北京市 100730
通讯作者：罗庆锋，100730，北京市东单大华路1号，北京医院消化内科. luoqf2000@sohu.com
电话：010-65132266-6142
收稿日期：2005-08-01 接受日期：2005-08-20
Changes of glucose metabolism in patients with liver cirrhosis: an analysis of 46 cases
Qing-Feng Luo, Le Xu, Liang Fu
Qing-Feng Luo, Le Xu, Liang Fu, Department of Gastroenterology, Beijing Hospital, Beijing 100730, China
Correspondence to: Qing-Feng Luo, Department of Gastroenterology, Beijing Hospital, 1 Dongdan Dahua Road, Beijing 100730, China. luoqf2000@sohu.com
Received: 2005-08-01 Accepted: 2005-08-20
Abstract
AIM: To investigate the changes of glucose metabolism and the possible mechanism.
METHODS: The levels of plasma glucose, insulin and C-peptide were measured in 46 patients with liver cirrhosis and 25 healthy people before (fasting) and 2 h after the oral glucose tolerance test (OGTT). The insulin sensitivity index (ISI) was calculated. All the results were analyzed comparatively.
RESULTS: In patients with liver cirrhosis, the levels of fasting plasma glucose and C-peptide were 5.58±2.14 mmol/L and 593±156 pmol/L, respectively (P >0.05); 2 h after OGTT, the levels of plasma glucose and C-peptide were 11.97±4.20 mmol/L and 3411±964 pmol/L, respectively, which were significantly higher than those in the healthy controls (P <0.05). In the liver cirrhosis patients, the levels of plasma insulin before (fasting) and 2 h after the OGTT were 12.23±5.4 mU/L and 105.16±40.70 mU/L, respectively, which were significantly higher than those in the healthy controls (P <0.05). The value of ISI in liver cirrhosis patients was significantly lower than that in the healthy controls (1.47±0.54 vs 2.73±0.62, P <0.05).
CONCLUSION: Abnormal glucose metabolism exists in patients with liver cirrhosis, and its mechanism may be related to the insulin resistance.
Key Words: Liver cirrhosis; Glucose metabolism; Insulin
Luo QF, Xu L, Fu L. Changes of glucose metabolism in patients with liver cirrhosis: an analysis of 46 cases. Shijie Huaren Xiaohua Zazhi 2005;13(17):2162-2164
摘要
目的：探讨肝硬化患者糖代谢变化及其可能的致病机制.
方法：对46例肝硬化患者及25例正常人分别测定空腹及口服75 g葡萄糖耐量试验(oral glucose tolerance test，OGTT)2 h后的血糖、血浆胰岛素及C肽水平，计算胰岛素敏感指数(insulin sensitivity index，ISI)，并对各项结果进行比较分析.
结果：肝硬化组空腹血糖、C肽水平分别为5.58±2.14 mmol/L、593±156 pmol/L，较对照组差异均没有显著性意义(P>0.05)；OGTT 2 h后血糖、C肽水平分别为：11.97±4.20 mmol/L、3411±964 pmol/L，均明显高于对照组(P<0.05)；而胰岛素测定结果可见肝硬化患者空腹及OGTT 2 h后胰岛素水平分别为：12.23±5.4 mU/L、105.16±40.70 mU/L，均明显高于对照组；肝硬化组ISI显著低于对照组(1.47±0.54vs 2.73±0.62，P<0.05).
结论：肝硬化患者存在明显的糖代谢异常，这种糖代谢异常与胰岛素抵抗有关.
关键词：肝硬化；糖代谢；胰岛素
罗庆锋，许乐，傅亮.肝硬化患者糖代谢变化临床分析46例. 世界华人消化杂志 2005;13(17):2162-2164
0 引言
肝脏对体内葡萄糖的代谢起着重要的调节作用，是维持血糖稳定的重要器官.而肝硬化是累及全身各脏器的慢性疾病.肝硬化患者合并糖尿病是影响生存期的一个危险因素，患者有较高的死亡率[4,8].为了探讨肝硬化患者糖代谢变化及其可能的发病机制 ......
您现在查看是摘要介绍页，详见PDF附件(1kb)。