肝移植前受体亚低温对急性肝衰大鼠移植肝脏的保护作用
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王志东, 韩德恩, 崔云甫, 姜明山, 张新宇,
急性肝衰竭;亚低温;肝移植;大鼠,王志东,韩德恩,崔云甫,姜明山,张新宇,曾兆林，,王志东，,通讯作者：,Moderatehypothermiath
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王志东, 韩德恩, 崔云甫, 姜明山, 张新宇, 曾兆林，哈尔滨医科大学附属第二医院肝胆外科 黑龙江省哈尔滨市 150086
王志东，男，1975-04-28生，黑龙江省兰西县人，汉族，2005年哈尔滨医科大学博士，主治医师，主要从事急性肝衰竭肝移植的临床与实验研究工作.
黑龙江省科技攻关资助项目，No.GB02C142-02
通讯作者：王志东，150086，黑龙江省哈尔滨市，哈尔滨医科大学附属第二医院肝胆外科. wzd98y2@sohu.com
电话：0451-86605117
收稿日期：2005-07-28 接受日期：2005-08-03
Moderate hypothermia therapy for acute liver failure in rats before liver transplantation
Zhi-Dong Wang, De-En Han, Yun-Fu Cui,Ming-Shan Jiang, Xin-Yu Zhang, Zhao-Lin Zeng
Zhi-Dong Wang, De-En Han, Yun-Fu Cui, Ming-Shan Jiang, Xin-Yu Zhang, Zhao-Lin Zeng, Department of Hepatobilliary Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Correspondence to: Department of Hepatobilliary Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China. wzd98y2@sohu.com
Received: 2005-07-28 Accepted: 2005-08-03
Abstract
AIM: To observe the effect of moderate hypothermia on the donated livers in rats with acute liver failure (ALF) before liver transplantation.
METHODS: ALF rats model were established by hepatectomy and hepatic devascularization. In situ liver transplantations were carried out for hypothermia treated group (35.0ºC) and the control group (37.5ºC) 12 h after the transplantation. Blood and tissue samples were collected just before and 6 or 24 h after transplantation. The concentrations of TNF-α were compared before and after the transplantation. The content of malondialdehyde (MDA) and the apoptotic rate of hepatic cells after the transplantation were observed. The apoptotic rate and MDA contents in donated liver were also assayed. The morphological changes of liver tissues were observed under microscope.
RESULTS: In the hypothermia treated group, the concentrations of TNF-α before and after the transplantation were significantly lower than those in the control group (19 ......
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