[摘要] 目的：探讨转移生长因子β2(transforming growth factor-β2,TGFβ2)多态性与非综合征性唇腭裂(nonsyndromic cleft lip with or without cleft palate, NSCL±P)的相关性。方法：应用聚合酶链反应-单链构象多态(PCR-SSCP)方法，以103名健康体检者为对照，配对研究了124名非综合征性唇腭裂患者TGFβ2基因的多态性。结果：对照组与患者组TGFβ2两者相比较，在统计学上有显著性差异(X2=16.235，df=1,P<0.005)；单独发生唇裂或腭裂者与唇腭裂同时并发者比较，在统计学上有显著性差异(X2=15.885，df=1,P<0.005)；其他配对比较均无统计学意义。结论：非综合征性唇腭裂的发生与TGFβ2基因多态性有相关性。

    [关键词] 唇腭裂 遗传学 转移生长因子β2 多态性

    Evidence for Association between Nonsyndromic Cleft Lip with or without Cleft Palate and Transforming growth factor-β2 Polymorphisms.

    JIAO Xiao-hui, WANG Li.

    The dental hospital Affiliated Hospital of Harbin medical university, Harbin 150001

    [Abstract]Objective: To study the relationship between transforming growth factor-β2(TGFβ2) polymorphisms and nonsyndromic cleft lip with or without cleft palate (NSCL±P) . Methods: TGFβ2 was examined by polymerase chain reaction-single strand conformation polymprphism (PCR-SSCP) technique in the 124 patients with NSCL±P and 103 healthy persons. Results: In the comparisons between the controls and the patients, the patients with cleft lip or cleft palate and the patients with cleft lip and palate, the results were respectively(X2＝16.235,df=1,P<0.005；X2＝15.885,df=1,P<0.005). So there was statistical significance. In other comparisons, there was no statistical significance. Conclusion: The above results give strong evidence for the association of TGFβ2 with development of NSCL±P. ......