[摘要] 目的：研究口腔鳞状细胞癌组织中COX-2和VEGF的表达及其临床意义。方法：用链霉素亲生物素-过氧化酶免疫组织化学(SP)法检测40例口腔鳞状细胞癌组织中COX-2和VEGF的表达，分析COX-2和VEGF表达与临床病理参数的关系以及COX-2表达与VEGF表达的相关性。结果：COX-2表达阳性率为47.5%(19/40)，VEGF表达阳性率为60%(24/40)。COX-2和VEGF的表达与口腔鳞状细胞癌患者的年龄、性别及组织分化程度无明显关系(P>0.05)，与临床分期和淋巴结转移有关。Ⅲ期与Ⅰ、Ⅱ期比较，原发灶中COX-2和VEGF表达率有升高趋势(P<0.05)。有淋巴结转移者与无淋巴结转移者比较，原发灶中COX-2和VEGF表达率有升高趋势(P<0.05)。COX-2表达与VEGF的表达呈正相关，COX-2阳性组与COX-2阴性组比较，原发灶中VEGF的表达呈升高趋势(P<0.05)。结论：COX-2和VEGF的表达与口腔鳞状细胞癌的增殖、浸润和转移有关，COX-2可能通过诱导血管生成而促进肿瘤浸润、转移，检测口腔鳞状细胞癌中COX-2和VEGF的表达有助于临床诊断和治疗。

    [关键词] 口腔鳞状细胞癌 COX-2 VEGF

    Expression of COX-2 and VEGF in Human Oral Squamous Cell Carcinoma.

    SUN Tao-jiao, XIONG Bin, CHEN Jian-gang, et al.

    Zhongnan Hospital, Wuhan University, Wuhan 430071

    [Abstrct]Objective: To explore the relationship between expression of COX-2 and VEGF and progression as well as, metastases of oral squamous cell carcinoma. Methods: The expression of COX-2 and VEGF were detected in 40 oral squamous cell carcinoma patients by immunohistochemical staining. The relationship between expression of COX-2 and VEGF and progression as well as metastases of oral squamous cell carcinoma was evaluated. Results: Among 40 cases of oral squamous cell carcinoma, 19 cases were positive for COX-2(47.5%), and 24 cases for VEGF(60%), respectively. The expression of COX-2 and VEGF were closely correlated with stage and lymph node metastasis of oral squamous cell carcinoma(P<0.05). Conclusion： COX-2 and VEGF were involved in progression and metastases of oral squamous cell carcinoma. The expression of COX-2 and VEGF will be helpful to the diagnosis and treatment of oral squamous cell carcinoma. ......