【摘要】 目的 探讨血清可溶性CD44v6(sCD44v6)含量与非小细胞肺癌(NSCLC)术后复发转移及中医辨证分型的关系。方法 采用定量酶联免疫反应法(ELISA法)测定26例NSCLC术后未复发转移患者、29例术后复发转移患者及30例正常人血清中可溶性CD44v6的含量，并对肺癌患者进行中医辨证分型。结果 NSCLC术后复发转移患者血清sCD44v6的含量明显高于术后未复发转移患者及正常人(P<0.001)；腺癌、鳞癌、鳞腺混合癌3组之间sCD44v6含量差异无显著性(P>0.05)；阴阳两虚型和阴虚型患者血清sCD44v6的含量明显高于脾虚痰湿型和气阴两虚型(P<0.001，P<0.01)。结论 血清sCD44v6与肺癌的进展和转移密切相关。sCD44v6可作为NSCLC术后监测病情进展、转移的指标，结合中医辨证分型有助于判断预后。

    【关键词】 非小细胞肺癌；sCD44v6；复发转移；辨证分型

    The clinical significance of serum sCD44v6 in NSCLC patients after operation

    ZHAO Li-hong，SUN Hui-li，XU Wei-jie，et al.

    Tumor Department of Longhua Hospital，Shanghai University of Traditional Chinese Medicine，Shanghai 200032，China

    【Abstract】 Objective To explore the relationship between the level of sCD44v6 of NSCLC and metastasis after operation or classification by differentiation in TCM.

    Methods Using ELISA to detect the quantity of sCD44v6 in different patients:26 cases of NSCLC without metastasis after operation ......