[摘要] 目的：通过对影响唇腭裂的可疑因素分析，旨在探讨其发病危险因素。方法：对我院2003年CLP及同期省人民医院的非CLP患儿和母亲进行病例对照研究，用非条件logistic回归分析来评价指标。结果：在10项指标中，唇裂伴或不伴腭裂(CL±P)单因素分析中有4项指标具有显著意义(P<0.05)，腭裂(CP)发病有5项指标具有显著意义(P<0.05)，分别进入Logistic逐步回归方程，结果表明家族史、母亲职业是CL±P发病的危险因素；患儿体重、母亲职业是CP发病的危险因素。结论：遗传因素在CL±P 的发病中具有显著意义，怀孕期间患病、用药可导致唇腭裂发病的相对危险度增加。

    [关键词] 唇裂 腭裂 logistic回归分析

    A Logistic Regression Analysis on Risk Factors of Cleft Lip and Palate.

    HU Qing, JIN Hui-xi, FU Yu-chuan.

    School of stomatology, Wuhan University, Wuhan 430079

    [Abstract]Objective: The purpose of this study is to evaluate the risk factors of cleft lip and palate (CLP). Methods: 508 CLP mothers and infants accompanied with 134 normal control pairs were studied. A logistic regression model to simple factor and multivariate analysis was used. Results: According to simple factor analysis, 4 factors were significant with cleft lip with or without palate(CL±P);5 factors were significant with cleft palate (CP).In the multiple logistic regression model, the family history and mother occupation were involved in CL±P, the infants height and mother occupation were involved in CP. Conclusion: The hereditary factor plays a significant role in CL±P. The relative risk of CLP could increase when mothers suffer from disease and take drugs in the period of pregnancy. ......