【摘要】 目的 探讨肝硬化患者血清一氧化氮(NO)与门脉血流及食管胃底静脉曲张破裂出血(EVB)之间的关系。 方法 60例肝硬化食管静脉曲张患者(EV);30例健康人(HS)，用多普勒超声测定门静脉(PVF)、肠系膜上静脉(SMF)及脾静脉血流参数(SVF);硝酸还原酶法测定血清NO，并随访1年。 结果 EV组血清NO值显著高于HS组;脾静脉与肠系膜上静脉血流之和显著高于HS组，且两者呈正相关(r=0.78)。血清NO异常升高者再出血率显著增加。 结论 肝硬化患者血清NO水平升高可能是引起内脏高动力状态进而引起食管胃底静脉曲张破裂出血的原因之一。

    【关键词】 食管胃底静脉曲张;一氧化氮;门脉血流

    Effects of serum nitric oxide on portal venous system flow and esophageal varices bleeding in patients with cirrhosis

    LUO Xiao-rong，CHEN Ni-wei.

    Department of Gastroenterology.the Sixth People's Hospital of Shanghai，Shanghai200233，China

    【Abstract】 Objective To explore the effects of serum nitric oxide(NO)on esophageal varices bleeding portal ve-nous system flow in patients with cirrhosis.Methods The parameter of portal venous flow(PVF)、splenic venous flow(SVF)、superior mesenteric flow(SMVF)were determined by Doppler ultrasonography;serumNO concentration with colorimetric assay were detected in60patients with cirrhosis and30healthy subjects(HS)on one year follow-up.Results Serum NO were significant difference between patients with esophageal varices and HS group.The sum of SVF and SMVF in patients with cirrhosis was greater than of normal controls.There were correlation between serum nitric oxide and the sum of SVF and SMVF in patients with cirrhosis(r=0.78).Bleeding rate of high serum NO group were markedly higher than that normal of group.Conclusion Level of serum nitric oxide may play important role in visceral hypertension circulation and esophageal varices bleeding in patients with cirrhosis. ......