肝病患者 IgA 和 sIgA 含量变化的临床意义
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刘冬妍, 刘 沛
IgA;sIgA;肝病,肝病患者IgA和sIgA含量变化的临床意义,刘冬妍,刘沛,通讯作者：,电话：,收稿日期：,接受日期：,ChangesofIgAandsIgAanditsclinicalsig
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刘冬妍, 刘沛, 中国医科大学附属第二医院传染科 辽宁省沈阳市 110004
通讯作者：刘沛, 110004，辽宁省沈阳市三好街36号，中国医科大学附属第二医院传染科. syliupei2003@yahoo.com.cn
电话：024-83956962
收稿日期：2005-06-30 接受日期：2005-07-15
Changes of IgA and sIgA and its clinical significant in hepatic diseases
Dong-Yan Liu, Pei Liu
Dong-Yan Liu, Pei Liu, Department of Infectious Diseases, the Second Affiliated of China Medical University, Shenyang 110004, Liaoning Province, China
Correspondence to: Pei Liu, Department of Infectious Diseases, the Second Affiliated Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, Liaoning Province,China. syliupei2003@yahoo.com.cn
Received: 2005-06-30 Accepted: 2005-07-15
Abstract
AIM: To investigate the values of IgA and sIgA detection in the clinical diagnosis of hepatic diseases.
METHODS: Patients with acute hepatitis (AH, n = 35), chronic severe hepatitis (CSH, n = 9), chronic hepatitis (CH, n = 67) and liver cirrhosis (LC, n = 57) were involved. The level of IgA was assayed by rate nephelometry, and the level of sIgA was detected by radioimmunoassay.
RESULTS: The levels of fecal IgA and sIgA were notably elevated in patients with AH, CSH, CH and LC as compared with those in the controls (IgA: 100±47, 251±178, 80±24, 145±164 mg/L vs <67 mg/L, P <0.01; sIgA: 88±96, 326±237, 88±121, 104±109 mg/L vs 13±10 mg/L, P <0.01). IgA was positively correlated with sIgA(r = 0.4371, P <0.01). The levels of serum IgA and sIgA were markedly increased in patients with AH, CSH, CH and LC as compared with those in the controls (IgA: 3.1±1.1, 3.4±1.8, 3.3±1.7, 4.9±3.3 g/L vs 1.6±0.2 g/L, P <0.01; sIgA: 31.1±25.8, 80.3±25.4, 30.5±24.1, 50.0±20.5 µg/L vs 23.4±8.2 µg/L, P <0.01 or P <0.05). The fecal IgA and sIgA were not correlated with serum IgA and sIgA, and serum IgA was not correlated with serum sIgA (P >0.05). In patients with CH, CSH and LC, serum sIgA was significantly correlated with alkaline phosphatase (r = 0 ......
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