全直肠系膜切除术切缘血管内皮生长因子检测的临床意义
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战学雷, 田素礼
直肠癌;直肠系膜远端切缘;直肠系膜周围切缘;盆筋膜壁层;全直肠系膜切除术;血管内皮生长因子,战学雷,田素礼,通讯作者：,电话：,收稿日期：,接受日
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战学雷, 田素礼, 哈尔滨医科大学附属第二医院普外三科 黑龙江省哈尔滨市 150086
通讯作者：战学雷, 150086, 黑龙江省哈尔滨市学府路246号, 哈尔滨医科大学附属第二医院普外三科. zhanxuelei@126.com
电话：0451-86605575
收稿日期：2005-05-28 接受日期：2005-06-13
Clinical significance of detection for vascular endothelial growth factor in resection margin following total mesorectal excision
Xue-Lei Zhan, Su-Li Tian
Xue-Lei Zhan, Su-Li Tian, the Third Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China
Correspondence to: Xue-Lei Zhan, Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China. zhanxuelei@126.com
Received: 2005-05-28 Accepted: 2005-06-13
Abstract
AIM: To investigate the expression and its significance of vascular endothelial growth factor (VEGF) in the resection margin following total mesorectal excision (TME) for human rectal cancer.
METHODS: VEGF was detected in the tissue specimens of cancer, distal mesorectal margin (DMM), circumferential resection margin (CRM) and outer pelvic fascia from 60 rectal cancer patients received TME. The pathological data were retrospectively analyzed.
RESULTS: VEGF expression was significantly higher in the tissues of rectal cancer than that in the normal tissues (54/60 vs 2/20, P <0.001). VEGF was also expressed in tissues of CRM (9/60). However, no VEGF expression was detected in the tissues of DMM and outer pelvic fascia. VEGF expression was closely related with the differentiation degree, Dukes staging and lymph node metastasis (P <0.05 or P <0.01).
CONCLUSION: VEGF is highly expressed in tissues of rectal cancer, and negatively or weakly positively expressed in DMM and CRM.
Key Words: Rectal cancer; Distal mesorectal margin; Circumferential resection margin; Outer pelvic fascia; Total mesorectal excision; Vascular endothelial growth factor ......
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