奥沙拉秦钠对溃疡性结肠炎一氧化氮合酶表达的影响
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郝俊鸣,江学良, 佟艳铭
溃疡性结肠炎; 奥沙拉秦钠; 一氧化氮合酶郝俊鸣,江学良,佟艳铭.奥沙拉秦钠对溃疡性结肠炎一氧化氮合酶表达的影响.世界华人消化杂志2005;13(19)2392-2394,奥沙
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郝俊鸣, 佟艳铭，首都医科大学康复医学院北京博爱医院内镜室北京市 100068
江学良 ，中国人民解放军济南军区总医院消化科山东省济南市 250031
通讯作者：江学良, 250031, 山东省济南市师范路25号,中国人民解放军济南军区总医院消化科. jiangxueliang678@126.com
电话: 0531-8381896.
收稿日期：2005-09-21 接受日期：2005-09-30
Effects ofolsalazine sodium on expression of nitric oxide synthase in patients withulcerative colitis: an analysis of 36 cases
Jun-Ming Hao, Xue-Liang Jiang, Yan-Ming Tong
Jun-Ming Hao, Yan-Ming Tong, Department of Endoscopy, BeijingCharity Hospital, Rehabilitation College of Capital University of MedicalSciences, Beijing 100068, China
Xue-Liang Jiang, Department of Gastroenterology, Chinese PLAGeneral Hospital of Ji nan Military Command Area, Ji nan 250031, ShandongProvince, China
Correspondence to: Xue-Liang Jiang, Department ofGastroenterology, Chinese PLA General Hospital of Ji nan Military CommandArea, 25 Shifan Road, Ji nan 250031, Shandong Province, China.jiangxueliang678@126.com
Received: 2005-09-21 Accepted:2005-09-30
Abstract
AIM: To explore the effects of olsalazine sodium on the expressionof nitric oxide synthase (NOS) in patients with ulcerative colitis (UC).
METHODS: The colonic mucosa specimens were collected from 36patients with active ulcerative colitis. The expression of inducible NOS(iNOS), epithelial NOS(eNOS), and nitrotyrosine were detected byimmunohistochemistry before and after the patients were treated witholsalazine sodium.
RESULTS: eNOS was expressed in the mucosal epithelial cells ofthe inflammatory area in 4 patients, but not expressed in the inflammatorycells. iNOS was expressed in the mucosal epithelial cells of all the 36(100%) samples (13 strong positive and 23 light positive) taken frominflammatory area. iNOS light positive staining in acinar cells of colonicepithelium was detected in 1 patient only. Inflammatory cells in thelamina propria expressed iNOS in 18 (50%) cases. After thetreatment of olsalazine sodium, iNOS was lightly and positively expressedin the mucosal epithelial cells of only 5 patients, and no iNOS wasexpressed in non-inflammatory areas. Nitrotyrosine was detected in themucosal epithelial cells of inflammatory areas in 5 patients, of whichonly 1 was accompanied by light and positive expression of nitrotyrosinein the acinar epithelial cells. No nitrotyrosine expression was found inthe inflammatory cells of the lamina propria and non-inflammatory areas.
CONCLUSION: Olsalazine sodium can inhibit the expression ofiNOS, alleviate the inflammation, and promote the healing of the ulcer.
Key Words:Ulcerative colitis; Olsalazine sodium; Nitric oxidesynthase
Hao JM, Jiang XL, Tong YM. Effects of olsalazine sodium on expression ofnitric oxide synthase in patients with ulcerative colitis an analysis of36 cases. Shijie Huaren Xiaohua Zazhi 2005;13(18):2392-2394
摘要
目的：探讨奥沙拉秦钠对溃疡性结肠炎一氧化氮合酶表达的影响 ......
郝俊鸣, 佟艳铭，首都医科大学康复医学院北京博爱医院内镜室北京市 100068
江学良 ，中国人民解放军济南军区总医院消化科山东省济南市 250031
通讯作者：江学良, 250031, 山东省济南市师范路25号,中国人民解放军济南军区总医院消化科. jiangxueliang678@126.com
电话: 0531-8381896.
收稿日期：2005-09-21 接受日期：2005-09-30
Effects ofolsalazine sodium on expression of nitric oxide synthase in patients withulcerative colitis: an analysis of 36 cases
Jun-Ming Hao, Xue-Liang Jiang, Yan-Ming Tong
Jun-Ming Hao, Yan-Ming Tong, Department of Endoscopy, BeijingCharity Hospital, Rehabilitation College of Capital University of MedicalSciences, Beijing 100068, China
Xue-Liang Jiang, Department of Gastroenterology, Chinese PLAGeneral Hospital of Ji nan Military Command Area, Ji nan 250031, ShandongProvince, China
Correspondence to: Xue-Liang Jiang, Department ofGastroenterology, Chinese PLA General Hospital of Ji nan Military CommandArea, 25 Shifan Road, Ji nan 250031, Shandong Province, China.jiangxueliang678@126.com
Received: 2005-09-21 Accepted:2005-09-30
Abstract
AIM: To explore the effects of olsalazine sodium on the expressionof nitric oxide synthase (NOS) in patients with ulcerative colitis (UC).
METHODS: The colonic mucosa specimens were collected from 36patients with active ulcerative colitis. The expression of inducible NOS(iNOS), epithelial NOS(eNOS), and nitrotyrosine were detected byimmunohistochemistry before and after the patients were treated witholsalazine sodium.
RESULTS: eNOS was expressed in the mucosal epithelial cells ofthe inflammatory area in 4 patients, but not expressed in the inflammatorycells. iNOS was expressed in the mucosal epithelial cells of all the 36(100%) samples (13 strong positive and 23 light positive) taken frominflammatory area. iNOS light positive staining in acinar cells of colonicepithelium was detected in 1 patient only. Inflammatory cells in thelamina propria expressed iNOS in 18 (50%) cases. After thetreatment of olsalazine sodium, iNOS was lightly and positively expressedin the mucosal epithelial cells of only 5 patients, and no iNOS wasexpressed in non-inflammatory areas. Nitrotyrosine was detected in themucosal epithelial cells of inflammatory areas in 5 patients, of whichonly 1 was accompanied by light and positive expression of nitrotyrosinein the acinar epithelial cells. No nitrotyrosine expression was found inthe inflammatory cells of the lamina propria and non-inflammatory areas.
CONCLUSION: Olsalazine sodium can inhibit the expression ofiNOS, alleviate the inflammation, and promote the healing of the ulcer.
Key Words:Ulcerative colitis; Olsalazine sodium; Nitric oxidesynthase
Hao JM, Jiang XL, Tong YM. Effects of olsalazine sodium on expression ofnitric oxide synthase in patients with ulcerative colitis an analysis of36 cases. Shijie Huaren Xiaohua Zazhi 2005;13(18):2392-2394
摘要
目的：探讨奥沙拉秦钠对溃疡性结肠炎一氧化氮合酶表达的影响 ......
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