奥曲肽联合汉防己甲素对人胃癌细胞增殖的影响
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王 龙, 朱金水, 陈维雄, 朱励, 达 炜, 王
生长抑素;汉防己甲素;奥曲肽;胃癌细胞;增殖;钙离子,王龙,朱金水,陈维雄,朱励,达炜，,王秀玲，,王龙,通讯作者：,Inhibitoryeffectsof
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王龙, 朱金水, 陈维雄,朱励, 达炜，上海交通大学附属上海市第六人民医院消化科 上海市 200233
王秀玲，上海交通大学附属新华医院消化科 上海市 200092
王龙, 男, 1971-10-09生, 陕西省泾阳县人, 汉族, 1997年上海第二医科大学硕士研究生, 主治医师, 目前为上海交通大学博士研究生, 主要从事胃癌的基础和临床研究.
通讯作者：王龙, 200233，上海市宜山路600号, 上海交通大学附属上海市第六人民医院消化科.wanglonglong@smmail.cn
电话：021-64369181-8969，8970 传真：021-64837019
收稿日期：2005-08-10 接受日期：2005-08-25
Inhibitory effects oftetrandrine combined with octreotide on proliferation of gastric cancercell lines cultured in vitro
Long Wang, Jin-Shui Zhu, Wei-Xiong Chen, Li Zhu, Wei Da, Xiu-Ling Wang
Long Wang, Jin-Shui Zhu, Wei-Xiong Chen, Li Zhu, Wei Da,Department of Gastroenterology, the Sixth Affiliated Shanghai People’s Hospital of Shanghai Jiaotong University, Shanghai 200233, China
Xiu-Ling Wang,Department of Gastroenterology, the Affiliated Shanghai Xinhua Hospital of Shanghai Jiaotong University, Shanghai 200092, China
Correspondence to: Dr. Long Wang, Department of Gastro-enterology, the Sixth Affiliated Shanghai People’s Hospital of Shanghai Jiaotong University, 600 Yishan Road, Shanghai, 200233, China. wanglonglong@smmail.cn
Received: 2005-08-10 Accepted: 2005-08-25
Abstract
AIM: To observe the inhibitory effects of tetrandrine (Tet), octreotide alone and in combination on the gastric cancer cell lines cultured in vitro, and to explore their possible mechanisms.
METHODS: The human gastric cell lines SGC7901 and MKN45 were cultured in vitro. The influences of Tet, octreotide alone and in combination on both kinds of the cells were observed by MTT spectrophotometry, and their effects on the concentration of cytosolic free Ca2+ were measured by Fura-2/AM.
RESULTS: Octreotide at high concentrations such as 2.4×10-5, 2.4×10-6mol/L, and Tet at concentrations of 10-160 μmol/L significantly inhibited the proliferation of SGC7901 and MKN45 cells, and the inhibitory rates (IR) were 40 ......
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