EB潜伏膜蛋白表达与肠上皮化生胃黏膜幽门螺杆菌感染的相关性
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刘东屏，于继红，李茵茵，王炳元
EB潜伏膜蛋白;肠上皮化生;幽门螺杆菌,刘东屏，于继红，王炳元,，,李茵茵，,刘东屏,通讯作者：,Relationshipbetweenex
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刘东屏，于继红，王炳元，中国医科大学附属第一医院消化内科 辽宁省沈阳市 110001
李茵茵，鞍山曙光医院肿瘤内科 辽宁省鞍山市 114000
刘东屏, 女, 1963-11-14生, 辽宁省辽阳市人, 汉族, 1985年中国医科大学本科毕业, 1988年硕士研究生, 1998年博士研究生, 副教授, 硕士研究生导师, 主要从事消化道肿瘤的研究.
通讯作者：刘东屏, 110001, 沈阳市和平区南京北街155号, 中国医科大学附属第一医院消化内科. dongpingl@yahoo.com.cn
电话：024-23256666-6199 传真：23329171
收稿日期：2005-05-23 接受日期：2005-06-08
Relationship between expression of Epstein-Barr virus latent membraneprotein and H pylori infection in gastric mucosa withintestinal metaplasia
Dong-Ping Liu, Ji-Hong Yu, Yin-Yin Li, Bing-Yuan Wang
Dong-Ping Liu, Ji-Hong Yu, Bing-Yuan Wang, Department ofGastroenterology, the First Affiliated Hospital of China MedicalUniversity, Shenyang 110001, Liaoning Province, China
Yin-Yin Li, Department of Oncology, Shuguang Hospital of Anshan,Anshan 114000, Liaoning Province, China
Correspondence to: Dong-Ping Liu, Department of Gastroenterology,the First Affiliated Hospital of China Medical University, Shenyang110001, Liaoning Province, China. dongpingl@yahoo.com.cn
Received:2005-05-23 Accepted:2005-06-08
Abstract
AIM: To observe the expression of Epstein-Barr virus latentmembrane protein(EBV-LMP) in different types of intestinalmetaplasia(IM), and to explore its relation with H pylori infection.
METHODS: One hundred and seventy-one patients with IM were diagnosedusing HE staining, and 30 normal cases were selected as controls.HID-AbpH2.5-PAS mucoprotein histochemical staining and SP histochemicalstaining were used to determine the subtypes of the IM and EBV-LMP,respectively. H pylori infection was examined by HE staining, Hpylori-DNA polymerase chain reaction, and enzyme linkedimmunosorbent assay.
RESULTS: There was no expression of EBV-LMP in the normal gastricmucosa, while the positive rate of EBV-LMP in the IM ones was 33.3% andthe EBV-LMP was mainly stained in the cell nuclei ......
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