摘 要：目的:探讨p53在甲状腺肿瘤中的表达意义。方法:用免疫组化SP法，检测30例甲状腺良性病变、100例甲状腺癌中p53的表达。结果:p53在正常甲状腺组织呈阴性表达，在甲状腺腺瘤、结节性甲状腺肿、甲状腺乳头状癌、滤泡癌、未分化癌表达阳性率分别为13.3%、13.3%、36.4%、42.9%、46.2%，与组织学类型密切相关(P<0.001)，其中良恶性病变之间差异有显著性(P<0.05)。结论:p53是鉴别甲状腺良恶性肿瘤及判断其生物学行为的重要指标。

    关键词： 甲状腺肿瘤； p53； 免疫组织化学

    The Expression and Significance of P53 in Thyroid Tumor

    AO Ya-zhou, SONG Li-gang, HU Jian-gong， et al

    (Affiliated Hospital to Chengde Medical College,Hebei Chengde 067000, China)

    Abstract: Objective: To study the significance of the expression of p53 in thyroid carcinoma.Method: Immunohistochemistry was used to detect the expression of p53 in 10 normal thyroid tissues, 30 thyroid benigh disease and 100 thyroid carcinoma. Result: No positive expression of p53 was found in normal thyroid tissues. The positite rate of p53 in thyroid adenoma, nodular goitre, papillary thyroid carcinoma, follicular thyroid carcinoma and undefferentediated carcinoma was 13.3%、13.3%、36.4%、42.9%、46.2% respectively. The expression of p53 was significantly correlated with the various pathologic types of them (P<0.001). Significantly differences of p53 expression can be seen between thyroid benigh and maligant tumor (P<0.05). Conclusion: p53 expression can be important factors for identifying the benigeh and maligant tumor and their biological behaviors. ......