摘 要:目的:探讨胃恶性间质瘤的免疫组化特征和临床诊治体会。 方法:对21例胃恶性间质瘤进行免疫组化染色，对其免疫表现、临床资料及随访结果进行分析。 结果:21例免疫组化结果示CD34均为阳性，而上皮指标细胞角蛋白(CK)和膜上皮抗体(EMA)大部分阴性；其中3例广泛转移者于术后4～6月死亡，姑息性切除2例，术后8月及9月均复发，其中1例再次手术，存活1年，其余16例均无瘤生存，生存期为3至6年。 结论:免疫组化检查可确定胃恶性间质瘤的恶性程度，手术应争取行根治性切除，对预后防止复发有积极意义。

    关键词: 胃肿瘤； 间质瘤

    Diagnose and Treatment of Stomach Malignant Stromal Tumors

    SUN Qin-li, ZHEN Hong-wei

    (Centre Hospital of Yishui,Shandong Linyi 276400,China)

    Abstract:Objective: To investigate the clinical diagnosis treatment and immunohistochemical characteristics of stomach malignant stromal tumors. Method: Immunohistochemical expression was retrieved in 21 cases of stomach malignant stromal tumors.And we analyzed the immunohistochemical characteristics,clinical data of stomach malignant stromal tumors,and the results retrospectively. Resut: The results of 21 cases of stomach malignant stromal tumors immunohistochemical were positive.The great mass of CK and EMA were negative.Among the 21 cases,3 patients of extensive metastasis were dead after operation,2 patients were given polypectomy,but they recured after operation 8 months and 9 months.One of them was operated again and lived 1 year,16 patients were disease-free survival 3 to 6 years. Conclusion: Immunohistochemical inspection can make sure the extend of malignancy of stomach malignant stromal tumors.The radical operation is the positive significance of prognosis and preventing recurrence. ......