【摘要】目的比较利培酮和舒必利治疗精神分裂症阴性症状的疗效和安全性。方法利培酮组20例，口服利培酮(1.34±0.52)mg/d；舒必利组20例，口服舒必利(618.2±108.3) mg/d，疗程均为8周。用阴性症状评定量表(SANS)评定疗效，用药物副反应量表(TESS)评定不良反应。用简易智能量表(MMSE)评定对认知功能的影响。结果临床总体疗效两组间无显著性差异(P>0.05)，利培酮组可提高MMSE的分值(P<0.01)。两组不良反应均以锥体外系症状为主，两组不良反应发生率无显著性差异(P>0.05)。结论利培酮和舒必利治疗精神分裂症阴性症状均有良好疗效，利培酮副反应小而安全，且不影响认知功能。

    【关键词】精神分裂症；阴性症状；利培酮；舒必利

    A control study of risperidone and sulpiride in the treatment of schizophrenia negative symptoms

    CHEN HongshengDONG XingpingWang Quanyinget al

    Binzhou People's Hospital,Binzhou 256610

    【Abstract】ObjectiveTo evaluate the efficacy and the safety of risperidone and sulpiride in treatment of schizophrenia negative symptoms.Methods20 patients had been given risperidone (1.34±0.52)mg/d for 8 weeks ......