【摘要】 目的 通过研究不同分化程度的胃癌与细胞凋亡及增殖的关系，探讨细胞凋亡在胃癌发生中的作用。方法 应用原位细胞凋亡TUNEL检测方法结合免疫组织化学染色方法对81例胃癌患者进行了细胞凋亡及增殖的原位观察和比较。结果 高中分化腺癌的凋亡指数明显高于低分化腺癌组,高中分化腺癌与低分化腺癌之间，高中分化腺癌与印戒细胞癌之间，低分化腺癌与黏液腺癌之间，印戒细胞癌与黏液腺癌之间，凋亡指数差异有非常显著性(P<0.01)。结论 分化差的胃癌细胞有逃避细胞凋亡的机制。细胞凋亡受抑制可能在胃癌的浸润和转移中发挥重要作用。高中分化腺癌的凋亡指数高于低分化腺癌，这可能是高中分化腺癌生长较缓慢，预后较好的原因之一。

    【关键词】 胃癌；分化程度；细胞凋亡

    Relationship between apoptosis and proliferation in differentiation of gastric cancer

    DING Hong-ji,WU Qi-song,DONG Yan-guang,et al.

    Department of Pathology,Shengli Oil Field Central Hospital, Dongying 257034,China

    【Abstract】 Objective To investigate action of apoptosis in gastric carcinogenesis by study the relationship between apoptosis and proliferation in gastric cancer.Methods TUNEL method was used to detect apoptotic cells,immunohistochemical staining was used to detect the expression of Ki-67 in 81 gastric carcinoma.Results In well and moderately differentiated adenocarcinomas the apoptotic indexes(AI)was significantly higher than poorly differentiated adenocarcinomas.The difference of AI was remarkably between well and moderately differentiated adenocarcinomas and poorly differentiated adenocarcinomas and signet-ring cell carcinomas,poorly differentiated adenocarcinomas and mucinous adenocaecinomas,signet-ring cell carcinomas and mucinous adenocarcinomas.Conclusion The poorly differentiated gastric carcinomas have a escape apoptosis mechanism.Apoptosis inhibited may exert important role in invasion and metastasis of gastric carcinomas. ......