【摘要】 目的 探讨垂体腺瘤经蝶窦入路手术并发脑脊液漏的防治。 方法 回顾性分析230例显微镜下经蝶窦垂体瘤切除术中，39例术中发生脑脊液漏。术中用自体脂肪、肌肉浆及耳脑胶修补，4例术后出现脑脊液鼻漏。 结果 用自体脂肪等修补39例脑脊液漏，其中35例术后未发生脑脊液漏;术后发生脑脊液漏4例，其中2例经腰穿脑脊液持续引流5天自愈，另2例须再次经蝶窦手术予以鞍底修补并治愈。无脑膜炎。 结论 应用自体脂肪、肌肉浆修补经蝶垂体腺瘤切除术中脑脊液漏是有效的方法，术后并发脑脊液漏应行腰穿脑脊液持续引流，1周内未治愈者应再次经蝶窦手术予以鞍底修补。

    【关键词】 脑脊液漏;垂体瘤;经蝶手术

    Prevention and treatment of cerebrospinal fluid leak during or after transsphe-noidal pituitary adenomas surgery

    LIN Fulu，YUE Zhi-jian，ZHOUXiao-ping，et al.

    Department of Neurosurgery，Second MilitaryMedical Univer-sity Changhai Hospital，Shanghai200433，China

    【Abstract】 Objective To explore the techniques for prevention and treatment of cerebrospinal fluid leak during or after transsphenoidal pituitary adenomas surgery.Methods Retrospective study of230patients received transsphe-noidal neurosurgery for resection of the pituitary adenomas.In the39patients with CSF leakage during surgery the sel-lar floors were sealed by free autogenic muscle mash ......