【摘要】 目的 初步探索盐酸戊乙奎醚注射液作为全麻术前用药减少腺体分泌的有效剂量并评价其安全性。方法 72例全麻病人随机分为3组,术前肌肉注射不同剂量盐酸戊乙奎醚注射液,剂量分别为0.0046mg/kg、0.0091mg/kg、0.0137mg/kg。测定注射后30min及术后1h的唾液分泌量，用视觉模拟评分方法测定口干程度并记录。结果 给药后30min，低、中、高剂量组唾液分泌量相对基线分别下降17.16%、25.00%、15.00%，给药后30min口干视觉模拟评分(VAS)均有增加，但组间无统计学差异。术后1h唾液分泌量与口干VAS评分结果与给药后30min相近。结论 盐酸戊乙奎醚注射液可以减少全麻术前唾液分泌，3个剂量组中中剂量组(0.0091mg/kg)对唾液分泌抑制最大。

    【关键词】 全身麻醉；抗胆碱药；盐酸戊乙奎醚；唾液分泌

    Dosage study of pnehyclidine hydrochloride as premedication of general anesthesia：a multicenter random double-blind dose-comparison trial

    YAN Mei, GUO Xiang-yang, YE Tie-hu,et al.

    Department of Anesthesia, Peking Union Medical College Hospital,Beijing 100730，China

    【Abstract】 Objective To determine the dosage of pnehyclidine hydrochloride as premedication of general anesthesia and evaluate the safety. Methods 72 patients who will receive general anesthesia were randomly allocated into 3 groups: received pnehyclidine hydrochloride as premedication, the dose were 0.0046mg/kg,0.0091mg/kg and 0.0137mg/kg. The secretion of salivary gland and VAS of thirst were examined 30 minutes after drug injection and 1 hour after operation. Results The secretion of salivary gland decreased and the VAS of thirst increased at the observed point, but there was no significant difference between the three groups.Conclusion As premedication of GA, pnehyclidine hydrochloride can decrease the secretion of salivary gland, the middle dose(0.0091mg/kg)was the most effective one. ......