化疗_____羟基喜树碱；化疗；晚期胃肠道癌

含羟基喜树碱联合化疗方案治疗晚期胃肠道癌临床观察

http://www.100md.com 《时珍国医国药》 2005年第9期

化疗,,羟基喜树碱；化疗；晚期胃肠道癌,1材料与方法,2结果,3讨论,参考文献：

     摘要：目的：观察含羟基喜树碱(HCPT)联合化疗(PF)方案对晚期胃肠道癌的疗效和毒性反应。方法：86例患者随机分为含HCPT的治疗组和不含HCPT的对照组，其它PF药物均相同。所有患者均至少完成2个周期以上PF。结果：含HCPT的治疗组总有效率为48.8%，对照组有效率为32.6%，有显著性差异(P<0.05)。两组主要毒性反应无明显增加。结论：HCPT方案联合化疗治疗晚期胃肠道癌，有效率高，毒副反应无明显增加，值得在临床中推广使用。

    关键词：羟基喜树碱；化疗；晚期胃肠道癌

    Clinical Observation of Treating Gastroenteric Carinoma with the Combinated Chemotherapy with Hydroxycamptothecin

    XU Xinqian, XIAO Jiping, ZHANG Li, LIU Dawen

    (The First Hospital of Huangshi, Huangshi, Hubei 435001, China)

    Abstract:Objective:To study the efficacy and toxicity in combination chemotherapy with hydroxycamptothecin(HCPT) in advanced gastroenteric carinoma.Methods:86 patients were randomly devided into two groups: the treatment group received a combined therapy of cisplatin, leucorin,5-fiuorouacil plus hydroxycamptothecyi, and the control group received cisplatin,leucorin,5-fiuorouracil without hydroxycamptothecin. The efficacy and toxicity in two groups were evaluated after two cycles.Results:The overall response was 48.8% in the treatment group and 32.6% in control group. There was significant difference between the two groups. The major toxicity of two groups included anorexia, vomiting, leukopenia, but there was significant difference between the two groups.Conclusion:The combination chemotherapy with HCPT is effective and safe for gastroenteric carcinoma. ......

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