排毒_____排毒双调综合疗法；慢性肾衰竭；5

排毒双调综合疗法对大鼠CRF细胞免疫影响的实验研究

http://www.100md.com 《时珍国医国药》 2005年第9期

排毒,,排毒双调综合疗法；慢性肾衰竭；5,6肾切除大鼠CRF模型；细胞免疫,1材料与方法,2实验方法,3结果,4讨论,参考文献：

     摘要：目的：观察排毒双调综合疗法对大鼠慢性肾功能衰竭的治疗作用及其可能的作用机理。方法：采用大鼠5/6肾切除动物模型，分为正常组、病理组、灌胃组、灌胃加灌肠及综合疗法组，观察各组大鼠治疗前后一般状况、血红蛋白(HGb)、肾功能(BUN、Scr)、外周血白细胞CD3+ T细胞、CD4+ T细胞、CD8+ T细胞的百分比及CD4+/CD8+的比值的变化。结果：综合疗法组较病理组、灌胃组、灌胃加灌肠组外周血白细胞中CD3+ T细胞、CD4+ T细胞、CD4+/CD8+比例均明显升高(P<0.05)，BUN、Scr亦较前述三组明显改善(P<0.01或P<0.05)，一般状况及贫血改善情况等也好于前述三组。结论：排毒双调综合疗法能减轻并延缓慢性肾衰竭的病理进展，且较单纯灌胃、灌胃加灌肠疗效为佳，其作用机理可能与改善细胞免疫功能有关。

    关键词：排毒双调综合疗法；慢性肾衰竭；5/6肾切除大鼠CRF模型；细胞免疫

    Experimental Uesearch on the Effect of Paidu-Shuangtiao Synthetic Therapy on the Immune Function of CRF Cells of Rats

    LI Xiaohui, DONG Zhenghua, ZHAO Runshuan, ZHAO Tiancai, PAN Long, ZENG Fuhai, YANG Jingfeng

    (Shanxi University of TCM, Xianyang, Shanxi 712083，China)

    Abstract:Objective:To observe the effect and the mechanism of Pai Du and Shuang Tiao synthetic therapy to the rats with chronic renal failure(CRF).Methods:Use experimental CRF rats with 5/6 nephrectomy animal model. Rats were divided into control group(A group), model group(B group), the single oral application therapy group(C group), the oral application+enema therapy group(D group)and synthetic therapy group (E group). The contents of HGb, blood urea nitrogen (BUN), serum creatinine(Scr), the detection of percentage of CD3+ T cell,CD4+ T cell, CD8+ T cell and CD4+/CD8+ were analyzed. Results:The percentage of CD3+ T cell, CD4+ T cell,CD4+/CD8+ is significantly improved in group E than that of other groups(P<0.05 ,P<0.05 ,P<0.05 );Scr and BUN of group E is lower than that of group B、C、D(P<0.01,P<0.05,P<0.05 ). Conclusion:Pai Du and Shuang Tiao synthetic therapy is able to improve cell mediated immunity and retard the progress of CRF ,and compared with single oral application, oral application + enema, the curative of synthetic therapy is the best. ......

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