【摘要】 目的 观察干扰素α1b治疗轮状病毒(RV)肠炎并肝脏损伤的临床疗效。方法 将126例RV肠炎并肝损伤患儿随机分为干扰素α1b治疗组和对照组进行比较分析。结果 对照组64例，治疗组62例；腹泻病疗效，对照组总有效75%，无效25%，治疗组总有效93.5%，无效6.5%；肝酶恢复慢的比例，对照组21.9%，治疗组3.2%。治疗组腹泻疗效、肝酶恢复正常比例均高于对照组，止泻时间比对照组缩短，差异均有显著性(P<0.01)。结论 重组人干扰素α1b治疗小儿RV肠炎并肝损伤能缩短病程，提高腹泻疗效，加速肝损伤愈合、降低肝酶恢复慢的比例。有临床实用价值，而且安全可行。

    【关键词】 肠炎；肝损伤；轮状病毒；干扰素；治疗

    Therapeutic effect of interferon α1b on rotavirus enteritis and liver lesion

    LIU Dong-cheng，XIAO Zhen，LI Yuan-bin.

    Department of Pediatrics，Xiaolan People’s Hospital，Zhongshan 528415,China

    【Abstract】 Objective To observe the therapeutic effect of interferon α1b on rotavirus enteritis and the liver lesion.Methods 126 cases of children with rotavirus enteritis and the liver lesion were randomly divided into 2 groups：64 cases of control group and 62 cases of treatment group treated with recombinant human interferon α1b.Results Therapeutic effect on the diarrhea disease：75% of the cases of control group and 93.6% of the cases of treatment group were effective. The slow recovery of ALT and AST：there were 21.9% of the cases in the control group ......