摘要：目的：探讨不同用法静脉输注丙种球蛋白(IVIG)治疗小儿川崎病的临床疗效。方法：对93例川崎病(KD)患儿采用两种不同治疗方案：A组为IVIG—1g/kg单次静脉输注；B组为IVIG 0.4g/kg.d,连用4～5d。对比两组治疗后冠状动脉病变(CAD)发生率和急性期临床症状消失时间。结果：川崎病发病10d内IVIG 1g/kg和0.4g/kg.d连用4～5d均能有效预防CAD的发生；急性期临床症状缓解方面：IVIG 1g/kg组明显优于IVIG 0.4g/kg.d组，差异有显著性。结论：IVIG 1g/kg单次静脉输注为治疗小儿川崎病经济方便和有效的方法。

    关键词：粘膜皮肤淋巴结综合征；免疫球蛋白类；静脉内；冠状动脉病变

    Analysis of Treating Kawasaki Disease with Intravenous Immunoglobulin

    HU Nv-yuan, YU Yong-fang, HUANG Jian-yu

    (Jiangmen Central Hospital, Guangdong Jiangmen 529070,China)

    Abstract： Objective： To explore the clinical effect of treating Kawasaki disease with different IVIG dosage. Method： 93 patients were divided into 2 groups with different dosage for the treatment: the dosage of Group A was IVIG 1g/kg only once, the dosage of Group B was IVIG 0.4g/ kg.d everyday, lasting 4～5 days. Result： CAD was effectively prevented by either 1g/kg or 0.4g/ kg.d(lasting 4～5 days) of IVIG within 10 days after the onset of the illness . On the remission of acute phrase symptoms, the regimen of 1g/kg IVIG was obviously better than the one of 0.4g/ kg.d IVIG. Conclusion： 1g/kg IVIG is an effective and economic dosage for the treatment of Kawasaki disease. ......