【摘要】 目的 探讨支原体(mycoplasma，Mp)感染与冠心病(coronary heart disease，CHD)之间的相关性。方法 采用酶联免疫吸附法(ELISA)检测冠心病组(50例)和对照组(47例)的血清Mp特异性抗体MpIgG、MpIgM；免疫透射比浊法(immunoturbidimetry)测定血清C-反应蛋白(CRP)；放射免疫法测定肿瘤坏死因子(TNF)和白细胞介素1β(IL-1β)的水平。结果 冠心病组MpIgG的阳性率。CRP、TNF、IL-1β含量水平，TNF、IL-1β阳性率均显著高于对照组(P<0.01)。结论 反复持久支原体感染与冠心病有关，可能是动脉粥样硬化的始动因子之一；Mp慢性感染者CRP、TNF、IL-1β含量水平，TNF、IL-1β阳性率均显著升高，可能是其通过炎症反应参与了冠心病的病理生理过程。

    【关键词】 冠状动脉疾病；支原体感染；C-反应蛋白

    Relationship between mycoplasma infection and coronary heart diseases

    HUANG Jin-cheng,JIN De-ming,ZHANG Guo-bing,et al.

    Department of Cardiovascular,Luodian Hospital,Baoshan,Shanghai 201908,China

    【Abstract】 Objective To study the relationship between mycoplasma(Mp) infection and coronary heart disease (CHD).Methods ELISA was used in measurement of specific serum antibody for Mp (MpIgG and MpIgM).CRP was measured by immunoturbidimetry,TNF and IL-1β were measured by radioimmunoassay.Results The positive ratio of MpIgG,TNF,IL-1β and also the levels of serum CRP,TNF,IL-1β were higher in CHD group than in contrast group (P<0.01).Conclusion Reoccurred and persistent mycoplasma infection is related to CHD,and this may be a start factor for atherosclerosis.Levels of CRP ......