摘要：目的：观察丹参注射液对Ⅱ型糖尿病肾病患者血液IL-6、IL-8和TNF-α的影响，探讨丹参注射液治疗Ⅱ型糖尿病肾病的机制。方法：采用丹参注射液治疗32例II型糖尿病肾病患者，取常规西药组32例作为对比观察，于治疗前后检测患者血液中细胞因子IL-6、IL-8和TNF-α水平。结果：丹参注射液治疗II型糖尿病肾病总有效率71.8%，而对照组总有效率为43.8%，两组比较差异有显著性；治疗前丹参注射液治疗组IL-8、IL-6和TNF-α水平与西医治疗对照组比较差异无显著性；治疗后两组IL-8、IL-6和TNF-α均显著降低，但丹参注射液治疗组下降更为明显，与西医治疗组比较差异有显著性；治疗后丹参注射液治疗组24h尿蛋白量显著低于对照组；且丹参注射液治疗组治疗前和治疗后24h尿蛋白量与IL-8、IL-6和TNF-α水平呈正相关。结论：丹参注射液结合西医治疗对II型糖尿病肾病有显著疗效，可能与丹参注射液能调节炎性细胞因子的产生，抑制炎症反应有关。

    关键词：丹参注射液；白细胞介素-8；白细胞介素6；肿瘤坏死因子-α；II型糖尿病肾病

    Effect of Salvia Miltiorrhiza Injection on IL-6、IL-8 and TNF-α in the Patients with Type Ⅱ Diabetic Nephropathy

    WANG Xiao-mei, ZHEN Zhuo-li, et al

    (The Affiliated Hospital of Guangdong Medical College, Guangdong Zhanjiang 524001, China)

    Abstract: Objective: To observe the effect of Salvia miltiorrhiza injection on IL-6、IL-8 and TNF-α in the patients with type Ⅱ diabetic nephropathy and to study the curing mechanism of Salvia miltiorrhiza injection to diabetic nephropathy. Methods: 32 patients with II type diabetic nephropathy were treated with Salvia miltiorrhiza injection, and 28 diabetic nephropathy patients remedied routinely were taken as contrasts. The levels of IL-6、IL-8 and TNF-α in the blood of patients were tested both before the treatment and after cure courses.Results: The total utility rate (71.8%) of Salvia miltiorrhiza injection to diabetic nephropathy was significantly higher than that of control group(43.8%). After the treatment, the levels of IL-6、IL-8 and TNF-α in the group treated with Salvia miltiorrhiza injection were lower than that of control group, and the 24h urine protein of Salvia miltiorrhiza injection treated group were significantly lower than that of control group. The 24h urine protein in Salvia miltiorrhiza injection treated group were positively correlated to IL-6、IL-8 and TNF-α. Conclusion: There was a significant treatment effect of Salvia miltiorrhiza injection on the patient with type Ⅱ diabetic nephropathy. The curing mechanism of Salvia miltiorrhiza injection to diabetic nephropathy may be this traditional Chinese medicine can regulate the production of inflammatory cytokins and can inhibit inflammatory reaction. ......