醒脑静注射乳剂的制备及其物理性质考察

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文章编号:(2005)03–0120–06,醒脑静注射乳剂的制备及其物理性质考察

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    朱华桥，逄秀娟，王思玲，汪贻广

    (沈阳药科大学 药学院，辽宁 沈阳 110016)

    摘要: 目的 制备醒脑静注射乳剂并对其物理性质进行初步考察。方法 用激光电泳­粒度测定仪、可见分光光度计、高分子渗透压计、酸度计、乌氏黏度计等仪器分别测定醒脑静注射乳剂的粒径及分布、Zeta电位、稳定性参数(K_e)、渗透压、pH值、黏度等；观察室温留样乳剂的粒径及输液配伍的稳定性。结果 醒脑静注射乳剂的Nicomp分布强度重量径为(176.8±24.0) nm，Zeta电位为–27.49 mV，稳定性参数(K_e)为2.9 %，渗透压稍偏高，pH值为7.20，黏滞系数为1.243 cp；醒脑静注射乳剂留样6个月粒径稍增大，与5 %葡萄糖、生理盐水配伍10 h内稳定。结论 醒脑静注射乳剂各项指标基本符合静脉注射制剂的要求。

    关键词：药剂学；物理性质；粒度测定；醒脑静注射乳剂；稳定性参数

    中图分类号：R943 文献标识码：A

    Preparation of Xingnaojing parenteral emulsion and studies on it’s physical properties

    ZHU Hua­qiao, PANG Xiu­quan, WANG Si­ling, WANG Yi­guang

    (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China)

    Abstract: Objective To prepare the Xingnaojing (traditional Chinese medicines) intravenous emulsion and determine several of it’s physical properties. Methods Physical properties such as emulsion particle size distribution, Zeta potential, stability constant(K_e), osmotic pressure, pH, viscosity were determined by laser electrophoresis­granularity meter, visible spectrophotometer, macromolecule osmotic pressure meter, acidimeter and viscosimeter, respectively; and the particle size distribution of emulsion after storage at room temperature for six months, and compatibility with several large volume parenterals were also studied ......

    http://www.100md.com/html/DirDu/2005/10/19/78/31/43.htm

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