聚合物纳米颗粒的制备及其应用(Ⅱ)

利用合成聚合物或天然大分子制备纳米颗粒

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文章编号：(2004)04-0091-09,利用合成聚合物或天然大分子制备纳米颗粒

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    徐晖¹，姬雅菊¹，王绍宁¹，李鸿滨²，郑俊民¹

    (1. 沈阳药科大学药学院，辽宁 沈阳 110016；2. 沈阳药大集琦药业有限责任公司，辽宁 沈阳 110016)

    摘要：目的 综述合成聚合物或天然大分子纳米颗粒的研究进展。方法 参考近期的文献，介绍合成聚合物，或蛋白、多糖类大分子纳米颗粒的形成原理和制备方法。结果和结论 乳化-溶剂挥发、乳化-溶剂扩散、凝聚法等方法可用来制备聚合物纳米颗粒。纳米颗粒可作为药物传递的胶体载体。

    关键词：药剂学；综述；纳米颗粒；合成聚合物；天然大分子

    中图分类号： R94 文献标识码：A

    Preparation and application of polymer nanoparticles (Ⅱ)

    Nanoparticles obtained from synthetic polymers or natural macromolecules

    XU Hui¹, JI Ya-ju¹, WANG Shao-ning¹, LI Hong-bin², ZHENG Jun-min¹

    (1 School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; 2 Shenyang Yaoda Jiqi Pharmaceutical Co. Ltd., Shenyang 110016, China)

    Abstract: Objective To review the recent advances on polymeric nanoparticles obtained from synthetic polymer or natural macromolecule. Methods According to the references in recent years, the method and principles of preparing nanoparticles through synthetic polymer, proteins or polysaccharides were discussed in details. Results and Conclusions Polymeric nanoparticles can be prepared by emulsion-solvent evaporation, emulsion-solvent diffusion, aggregation, and other method. Such nanoparticles may be used as colloidal carriers for drug delivery.

    Key words: pharmaceutics; review; nanoparticle; synthetic polymer; natural macromolecule

    http://www.100md.com/html/DirDu/2005/10/19/78/32/39.htm

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