一阶导数分光光度法测定氟比洛芬微乳的含量
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吴顺芹1，李三鸣1，刘天富2，徐 璐1，赵国斌3
(1.沈阳药科大学药学院，辽宁 沈阳 110016； 2.哈尔滨泰华药业有限公司，黑龙江 哈尔滨 150302；3.吉林省药品检验所，吉林长春 130062)
摘要：目的 探讨氟比洛芬微乳的含量测定方法。 方法 采用一阶导数分光光度法。一阶导数光谱条件：波长范围为240～360 nm,振幅值范围为−0.6～0.6，测定狭缝为2 nm, △λ为2 nm,扫描速度为快速扫描。 结果 氟比洛芬质量浓度在5.02～50.2 mg•L-1时线性关系良好，相关系数为r=0.999 9；方法的日内日间精密度好；平均回收率为 100.2 %，RSD为 0.95 %。 结论 一阶导数分光光度法适用于氟比洛芬微乳的含量测定。
关键词：药剂学；微乳；一阶导数分光光度法；氟比洛芬
中图分类号：R 917 文献标识码：A
Determination of the contents of flurbiprofen in the microemulsions by the first-order derivative spectrophotometry
WU Shun-qin1，LI San-ming1，LIU Tian-fu2, XU Lu1, ZHAO Guo-bin3
(1.School of Pharmacy，Shenyang Pharmaceutical University，Shenyang 110016，China；2.Harbin Taihua Pharmaceutical Corp.，Ltd.，Harbin 150302， China; 3. Jinlin Province Institute for Drug Control ,Changchun 130062, China)
Abstract：Objective To develop a sensitive，accurate and rapid method to determine flurbiprofen in the microemulsions. Methods A first-order derivative spectrophotometry method was used. The range of wave length and amplitude were 240～360 nm and −0.6～0.6，respectively. The slit width was 2 nm and △λ was 2 nm. The scan speed was fast. Results The linear calibration curves were obtained in the concentration range of 5.02～50.2 mg•L-1(r=0.999 9). The within-day and between-day precision were good. The mean recovery was 100.2%，RSD was 0.95%. Conclusion The method is simple，rapid，accurate and suitable for the determination of flurbiprofen in the microemulsions.
Key words：pharmaceutics; microemulsions; first-order derivative spectrophotometry ; flurbiprofen
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