阿昔洛韦纳米乳剂在大鼠体内的药代动力学
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文章编号：(2004)03-0037-06,阿昔洛韦纳米乳剂在大鼠体内的药代动力学
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段明华，王东凯, 马淑飞
(沈阳药科大学药学院，辽宁 沈阳110016)
摘要：目的 制备阿昔洛韦纳米乳剂，探讨其在大鼠体内的药代动力学。方法 对大鼠尾静脉注射后不同时间点眼眶采血，用HPLC法测定阿昔洛韦血药浓度,3p87软件拟合药动学参数。结果 阿昔洛韦在大鼠体内呈二室模型，t1/2α为20.74 min, t1/2β为380.87 min,清除率(CL)为0.001 8。结论 将阿昔洛韦制成纳米乳剂可提高其相对生物利用度，从而增强其抗病毒作用。
关键词：药剂学; 大鼠体内药代动力学;高效液相色谱法;阿昔洛韦纳米乳剂
中图分类号：R96 文献标识码：A
Study on the pharmacokinetics of acyclovir nanemulsions in rats
DUAN Ming-hua, WANG Dong-kai, MA Shu-fei
(School of Pharmacy , Shenyang Pharmaceutical University，Shenyang 110016,China)
Abstract: Objective To study the pharmacokinetics of acyclovir nanemulsions in rats. Methodes The blood samples were collected at different times after administration in rats .The plasma concentrations of acyclovir were determined by HPLC.The pharmacokinetic parameters were calculated by a pharmaceutic soft ware named 3p87 . Results Acyclovir was disposed as a two-compartment model in rats . Conclusions The anti-virus function of acyclovir are improved by use of nanoemulsion.
Key words: pharmaceutics; pharmacokinetics ; HPLC; nano-acyclovir
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