肝靶向葫芦素B聚乳酸-羟基乙酸毫微球的小鼠体内分布研究

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     王丹蕾^{1, 2}，陈大为¹，郭 涛²，罗轶凡¹，赵秀丽¹，李可欣¹

    (1.沈阳药科大学 药学院，辽宁 沈阳 110016； 2.沈阳军区总医院 药剂科， 辽宁 沈阳 110016)

    摘要：目的 研究葫芦素B聚乳酸­羟基乙酸毫微球小鼠体内分布。方法 小鼠尾静脉给药， HPLC法测定葫芦素B在小鼠血浆、心、肝、脾、肺、肾、脑中的浓度。结果 葫芦素B聚乳酸­羟基乙酸毫微球主要分布于肝，给药15 min，肝中聚集达最大，为给药剂量的47.15%。结论 葫芦素B聚乳酸­羟基乙酸毫微球可实现肝脏被动靶向，所建立的HPLC法用于葫芦素B的体内分布研究，结果良好。

    关键词：药剂学；聚乳酸­羟基乙酸毫微球体内分布；HPLC法；葫芦素B；肝脏靶向性

    中图分类号：R94 文献标识码：A

    Study on the distribution of the liver targeted cucurbitacin B loaded PLGA nanospheres in mice

    WANG Dan-lei^1,2, CHEN Da-wei¹, GUO Tao², LUO Yi-fan¹, ZHAO Xiu-li¹, LI Ke-xin¹

    (1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China；2. The General Hospital of Shenyang Military Region,Shenyang 110016，China)

    Abstract: Objective To study the distribution of cucurbitacin B loaded PLGA nanospheres in mice. Methods After admistration to mice by iv, HPLC was used to determine the concentration of cucurbitacin B of plasma, heart, liver, spleen, lung, kidney and brain respectively. Results The distribution of cucurbitacin B in liver was significantly higher than that in any other organs. At 15 min, the uptake of liver reached a maximum, about 47.15% of the dose. Conclusion Cucurbitacin B loaded PLGA nanospheres show passive targeting to liver. The established HPLC method can be used for cucurbitacin B biodistribution study.

    Key words: pharmaceutics; PLGA nanospheres biodistribution; HPLC; cucurbitacin B; liver targeting

    http://www.100md.com/html/DirDu/2005/10/19/78/34/44.htm

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