几种大分子分散系动态光散射光谱分析

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文章编号：(2003)03-0107-06,几种大分子分散系动态光散射光谱分析

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    王思玲¹，李玉娟²，王立强¹，Greg Pokrajac³, David Nicoli³

    (1.沈阳药科大学药学院，辽宁 沈阳110016; 2.沈阳药科大学基础学院，辽宁 沈阳110016;3.美国NICOMP公司,加州圣巴巴拉)

    摘要：目的 分析大分子分散系的粒子大小与分布，了解动态光散射光谱的应用。方法 以激光粒径仪测定各分散体系的动态光散射光谱,得各体系粒子大小的体积–重量频率分布及散射强度–重量频率分布图。 结果 各体系粒子大小与分布不同，动态光散射光谱有显著差别。结论 动态光散射技术对分散系粒子大小分析有重要的指导意义。

    关键词：药剂学；动态光散射；大分子；分散系；粒径大小；分布；分析

    中图分类号：R943 文献标识码：A

    Analysis of dynamic light scattering (DLS) spectra of some macromolecule dispersions

    WANG Si–ling¹，LI Yu–juan², WANG Li–qiang¹, GREG Pokrajac³, DAVID Nicoli³

    (1 School of Pharmacy，Shenyang Pharmaceutical University，Shenyang 110016,China; 2. School of Basic Courses, Shenyang Pharmaceutical University, Shenyang 110016,China;3. NICOMP Company, Santa Barbara, California, U.S.A)

    Abstract：Objective To analyse particle size distribution and understand the application of Dynamic Light Scattering (DLS) Methods Their volume-weighted particle size distribution, PSD_V for macromolecules and the corresponding intensity-weighted, PDS_I, for the same samples were obtained by the Laser Diffraction Particle Size Analyzer. Results The particle size distribution is different for the dispersions as shown in Figures 1~5. Conclusion The DLS technique will have an important place in estimating the particle size distribution of macromolecules.

    Key words: pharmaceutics; dynamic light scattering; macromolecules; dispersion; particle size ; distribution; analysis

    http://www.100md.com/html/DirDu/2005/10/19/78/35/36.htm

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