磷脂对双氢杨梅黄素理化性质的影响
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袁永越1，郑剑峰2，刘 影1，于治国1
(1.沈阳药科大学 药学院，辽宁 沈阳 110016；2.光大制药有限公司，辽宁 沈阳 110141)
摘要: 目的 研究磷脂对双氢杨梅黄素理化性质的影响。方法 采用溶剂挥发法，对以乙醇为溶剂得到双氢杨梅黄素经磷脂处理后的样品，进行热分析、X-射线衍射分析；对其在水和正辛醇中的溶解度及油水分配系数进行测定。结果 与双氢杨梅黄素比较，经磷脂处理后的样品在热分析及X-射线衍射分析谱图中发生明显变化，晶体特征消失；处理后的样品在水和正辛醇中的溶解度分别提高了12倍和73倍，油水分配系数也有所增大。结论 双氢杨梅黄素经磷脂处理后的理化性质发生较大改变。
关键词: 药剂学；理化性质；溶剂挥发法；双氢杨梅黄素
中图分类号: R944.2 文献标识码：A
Influence of phospholipid on the physico-chemical properties of dihydromyricetin
YUAN Yong-yue1，ZHENG Jian-feng2，LIU Ying1，YU Zhi-guo1
(1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016,China; 2. Guangda Pharmaceutical Co.,Ltd, Shenyang 110141,China)
Abstract: Objective To study the influence of phospholipid on the physico-chemical properties of dihydromyricetin. Method Solvent evaporation method was used to prepare dihydromyricetin sample which was treated with phospholipid with ethanol as the solvent. Its characteristics in DSC and X-ray diffraction spectra were investigated, and its apparent partition coefficients in the system of n-octyl alcohol and water were determinted. Result Compared with dihydromyricetin, much changes of characteristics in DSC and X-ray diffraction were found in the spectra of the treated sample,the character of crystal disappeared and the solubility of treated sample both in water and in n-octyl alcohol was improved 12 times and 73 times, and the apparent partition coefficients was increased greatly. Conclusion The physico-chemical properties of treated sample can be greatly changed.
Key words: pharmaceutics; physico-chemical properties; solvent evaporation; dihydromyricetin
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